Interní Med. 2006; 8(11): 502-504

Significance of the evaluation of serum levels of immunoglobulins free light chains in monoclonal gammopathies

MUDr. Elena Šumná1, RNDr. Ludmila Nováčková2, doc. MUDr. Arnošt Martínek CSc3, prof. MUDr. Vlastimil Ščudla CSc4
1 1. hematologická ambulance, Ostrava Vítkovice
2 Ústav klinické biochemie, FNsP Ostrava
3 Interní klinika, FN v Ostravě-Porubě
4 III. interní klinika FN a LF UP Olomouc

There is a presentation of the most important laboratory methods used for the evidence and quantification of monoclonal immunoglobulins and their structure components in serum and urine. The new applicated automated immunochemical methods allow to evaluate with high sensitivity and specificity the quantitative values of free light chains of immunoglobulins in serum (s-FLC). The estimation of s-FLC concentration, ratio kappa/lambda and their changing allows us significantly to extend the current spectrum of regularly used methods in diagnostics and assessment of results of the treatment of individual types of monoclonal gammopathies.

Keywords: Key words: monoclonal gammopathy, free light immunoglobulin chains, automated immunochemical analysis, diagnostics, treatment.

Published: March 1, 2007  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Šumná E, Nováčková L, Martínek A, Ščudla V. Significance of the evaluation of serum levels of immunoglobulins free light chains in monoclonal gammopathies. Interní Med. 2006;8(11):502-504.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Abraham RS, Bergen RH, Naylor S et al. Characterisation of free Immunoglobulin Light Chains (LC) by Mass spectrometry in Light Chain-Associated (AL) Amyloidosis. Blood 2001; 98: 3722.
    2. Adam Z, Hájek R, Mayer J, Ščudla V. et al. Mnohočetný myelom a další monoklonální gamapatie 1. vydání Brno, LF MU, 1999; 367 s.
    3. Adam Z, Česká myelomová skupina. Doporučení pro diagnostiku a léčbu mnohočetného myelomu. Trans Hemat dnes 2003; 9 (suppl): 3-33.
    4. Bradwell AR. Mead GP Carr-Smith HD Serum free light Chain analysis 3rd Edition Birmingham, The Binding Site Ltd. 2005: 292 p.
    5. Bradwell AR Carr-Smith HD, Mead GP, Drayson MT. Serum free light Chain immunoassays and their clinical application. Clin.applied Immunol Rev 2002; 3: 17-33. Go to original source...
    6. Drayson MT, Tang LX, Drew R, Mead GP, Carr-Smitth HD Bradwell AR, Serum free light-chain measurements for identifying and monitoring patiens with nonsecretory multiple myeloma. Blood 2001; 97: 2900-2902. Go to original source... Go to PubMed...
    7. Engliš M. Stanovení volných lehkých řetězců imunoglobulinů v séru v diagnostice a monitorování monoklonálních gamapatií. http://www.cscb.cz/vzdelavani/light-chain.htm.
    8. Katzmann JA, Clark RJ, Abraham RS et al. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: Relative sensitivy for detection of monoclonal light chains. Clin Chem 2002; 48: 1437-1444. Go to original source...
    9. Kyle RA, Thermeau TM, Rajkumar SV et al. A long-term Study of Prognosis in Monoclonal Gammopathy of Undetermined Significance. New Eng J Med 2002; 346: 546-569. Go to original source... Go to PubMed...
    10. Kyle RA, Greipp PR., ,Idiopathic" Bence Jones Proteinuria. New Eng J.Med 1982; 346: 564-569. Go to original source... Go to PubMed...
    11. Lachmann HJ, Gallimore R, Glilmore JD et al. Outcome in systemic free immunoglobulin light chains following chemotherapy. Brit J Haematol 2003. 122: 78-84. Go to original source... Go to PubMed...
    12. Masopust J. Klinická biochemie požadování a hodnocení biochemických vyšetření II. část UK, 1998: 540-544.
    13. Rajkumar SV Kyle RA,Therneau TM et al. Presence of Monoclonal Free Light Chains in Serum Predicts Risk of Progression in Monoclonal Gammopathy of Undetermined Significance. Blood 2003; 102: 3481.
    14. Ščudla V, Vytřasová M, Minařík J. et al. Klinický význam hodnocení sérových hladin volných lehkých řetězců imunoglobulinů u monoklonálních gamapatií, Trans Hemat dnes 2005, 2 47-53.
    15. Ščudla V, Minařík J, Schneiderka P, et al. Význam sérových hladin monoklonálních volných lehkých řetězců imunoglobulinu v diagnostice a hodnocení aktivity mnohočetného myelomu a vybraných monoklonálních gamapatií. Vnitř. Lék 2005; 51: 1249-1257.
    16. Špička Ivan et al. Mnohočetný myelom a další monoklonální gamapatie Praha, Galén, 2005; 11-107.

    Return to the content


    Internal Medicine for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.