Interní Med. 2016; 18(1): 49-51

What is the C-reactive protein and how to correctly evaluate its elevated serum levels?

MUDr. Pavel Polák, Ph.D.0,2,3, prof. MUDr. Hana Matějovská-Kubešová, CSc.0,2
1 Oddělení klinické hematologie, Fakultní nemocnice Brno
2 Klinika interní, geriatrie, ošetřovatelství a praktického lékařství, Fakultní nemocnice Brno
3 Lékařská fakulta Masarykovy univerzity Brno

The work is dedicated to the pathophysiology of inflammatory processes leading to the C-reactive protein (CRP) synthesis and to its immune functions. The understanding of possible infectious and non-infectious causes leading to CRP-synthesis as well as understanding of the dynamics of its synthesis and degradation and of the role of elevated CRP levels in the indication of antibiotic treatment are emphasized.

Keywords: C-reactive protein, inflammation, autoimmune disease, tumor, antibiotic treatment

Published: February 1, 2016  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Polák P, Matějovská-Kubešová H. What is the C-reactive protein and how to correctly evaluate its elevated serum levels? Interní Med. 2016;18(1):49-51.
Download citation

References

  1. Mukerji R, Mirza S, Roche AM, et al. Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface phosphocholine. J Immunol. 2012; 189(11): 5327-5335. Go to original source...
  2. Reiner AP, Beleza S, Franceschini N, et al. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. Am J Hum Genet. 2012; 91(3): 502-512. Go to original source...
  3. Du Clos TW. Pentraxins: structure, function, and role in inflammation. ISRN Inflamm. 2013; 2013: 379040. Go to original source... Go to PubMed...
  4. Lu J, Marjon KD, Mold C, et al. Pentraxins and Fc receptors. Immunol Rev. 2012; 250(1): 230-238. Go to original source... Go to PubMed...
  5. Braunschweig A, Józsi M. Human pentraxin 3 binds to the complement regulator c4b-binding protein. PLoS One. 2011; 6(8): e23991. Go to original source... Go to PubMed...
  6. Mihlan M, Blom AM, Kupreishvili K, et al. Monomeric C-reactive protein modulates classic complement activation on necrotic cells. FASEB J. 2011; 25(12): 4198-4210. Go to original source... Go to PubMed...
  7. Perkins SJ, Okemefuna AI, Nan R. Unravelling protein-protein interactions between complement factor H and C-reactive protein using a multidisciplinary strategy. Biochem Soc Trans. 2010; 38(4): 894-900. Go to original source... Go to PubMed...




Internal Medicine for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.