Interní Med. 2000; 2(10)

Substituce hormonů štítné žlázy - jeden hormon nebo dva?

Published: December 31, 2000  Show citation

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Substituce hormonů štítné žlázy - jeden hormon nebo dva? Interní Med. 2000;2(10):.

NEJM, 340, 2000, s. 469-470.

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MUDr. Dalibor Musil, PhD.

Extrakty ze štítné žlázy zvířat, poprvé použité v r. 1892, obsahovaly tyroxin (T4) a trijodtyronin (T3) a 50 let byly jedinou dostupnou léčbou hypotyreózy. Léčba extrakty štítné žlázy vedla k vysoké sérové koncentraci T3, který se rychle vstřebává a někteří nemocní proto měli jednu nebo dvě hodiny po podání palpitace. U syntetického T4 se obdobné potíže neobjevily a léčba také nebyla provázená výrazným kolísáním koncetrací T3.

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