Interní Med. 2010; 12(7-8): 350-354

Diabetes mellitus and wound healing

MUDr.Vladimíra Fejfarová, Ph.D.
Centrum diabetologie, IKEM, Praha

Wound healing could be impaired by a range of factors including diabetes mellitus and relating metabolic changes influencing wound

healing on biochemical and cell levels. Impaired wound healing in patients with diabetes mellitus is caused also by higher incidence

of infectious complications, vascular changes at the level of microangiopathy and macroangiopathy and in several cases by repetitive

pressure on wound amplifying local ischemia. The field of wound healing is a complex of concerns; therefore we always pay attention to

the control of many parameters. The wound treatment comes based on wound etiology under the competence of many specialists – dermatologists,

surgeons, geriatrists etc., the diabetic foot is mostly treated by diabetologists or surgeons experienced in podiatric care.

Keywords: wound healing, local factors, systemic factors, diabetes mellitus

Published: August 12, 2010  Show citation

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Fejfarová V. Diabetes mellitus and wound healing. Interní Med. 2010;12(7-8):350-354.
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    References

    1. International Consensus on the Diabetic Foot by the International Working Group on the Diabetic Foot, 1999.
    2. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest 2007; 117(5): 1249-1259. Go to original source... Go to PubMed...
    3. Jeffcoate WJ, Price P, Harding KG. Wound healing and treatment for people with diabetic foot ulcers. Diabetes Metab Res Rev 2004; 20(Supp 11): S78-S89. Go to original source... Go to PubMed...
    4. Peppa M, Stavroulakis P, Raptus SA. Advanced glycoxidation products and impaired diabetic wound healing. Wound Repair Regen 2009; 17(4): 461-472. Go to original source... Go to PubMed...
    5. Spravchikov N, Sizyakov G, Gartsbein M, et al. Glucose effects on skin keratinocytes: implications for diabetes skin complications. Diabetes 2001; 50: 1627-1635. Go to original source... Go to PubMed...
    6. Laing T, Hanson R, Chan F, et al. The role of endotelial dysfunction in the pathogenesis of impaired diabetic wound healing: A novel therapeutic target? Med Hypotheses 2007: 12. Go to original source... Go to PubMed...
    7. Köveker GB. Growth factors in clinical practice. Int J Clin Pract 2000; 54(9): 590-593. Go to PubMed...
    8. Blakytny R, Jude EB, Martin Gibson J, et al. W. Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. J Pathol 2000; 190(5): 589-594. Go to original source... Go to PubMed...
    9. Singh AK, Gudehithlu KP, Patri S, et al. Impaired integration of endothelial progenitor cells in capillaries of diabetic wounds is reversible with vascular endothelial growth factor infusion. Transl Res 2007; 149(5): 282-291. Go to original source... Go to PubMed...
    10. Burrow JW, Koch JA, Chuang HH, et al. Nitric oxide donors selectively reduce the expression of matrix metalloproteinases-8 and -9 by human diabetic skin fibroblasts. J Surg Res 2007; 140(1): 90-98. Go to original source... Go to PubMed...
    11. King, L. Impaired wound healing in patients with diabetes. Nurs Stand 2001; 15(38): 39-45. Go to original source... Go to PubMed...
    12. Albertson S, Hummel RP, Breeden M, et al. PDGF and FGF reverse the healing impairment in protein-malnourished diabetic mice. Surgery 1993, 114(2): 368-372. Go to PubMed...
    13. Rai NK, Tripathi K, Sharma D, et al. Apoptosis: a basic physiological process in wound healing. Int J Low Extrem Wounds 2005; 4(3): 138-144. Go to original source... Go to PubMed...
    14. Yue D, Swanson B, McLennan S, et al. Abnormalities of granulation tissue and collagen formation in experimental uraemia and malnutrition. Diabet Med 1986; 3(3): 221-225. Go to original source... Go to PubMed...
    15. Criado E, De Stefano AA, Keagy BA, et al. The course of severe foot infection in patients with diabetes. Surgery, Gynecology & Obstetrics 1992; 175(2): 135-140.
    16. Schaper NC. Diabetic foot ulcer classification system for research purposes: a progress report on criteria for including patients in research studies. Diabetes Metab Res Rev 2004; 20(Suppl 1): 90-95. Go to original source... Go to PubMed...
    17. Jirkovská, A. Diabetická noha. In Bartoš V, Pelikánová T. (ed). Praktická diabetologie, 2nd edit., Praha: Maxdorf, 2000; 305-325.
    18. Jirkovská A. Syndrom diabetické nohy. 1st edit., Praha: Jesenius Maxdorf, 2006.
    19. Lavery LA, Walker SC, Harkless LB, et al. Infected Puncture Wounds in Diabetic and Nondiabetic Adults. Diabetes Care 1995; 18(12): 1588-1591. Go to original source... Go to PubMed...
    20. Armstrong DG, Lipsky BA. Diabetic foot infection: stepwise medical and surgical management. Int Wound J 2004; 1(2): 123-132. Go to original source... Go to PubMed...
    21. Caputo GM, Cavanagh PR, Ulbrecht JS, et al. Assessment and management of foot disease in patients with diabetes. N Engl J Med 1994; 331: 854-860. Go to original source... Go to PubMed...
    22. Lipsky BA, Berendt AR. Principles and practice of antibiotic therapy of diabetic foot infections. Diabetes Metab Res Rev 2000; 16(Suppl 1): S42-46. Go to original source... Go to PubMed...
    23. Fejfarová V, Jirkovská A, Petkov V, et al. Comparison of microbial findings and resistance to antibiotics between transplant patients, patients on hemodialysis, and other patients with the diabetic foot. J Diabetes Complications 2004; 18(2): 108-112. Go to original source... Go to PubMed...
    24. Gupta AK, Konnikov N, McDonald P, et al. Prevalence and epidemiology of toenail onychomycosis in diabetic subjects: a multicenter survey. British Journal of Dermatology 1998; 139: 665-671. Go to original source... Go to PubMed...
    25. Chincholikar DA, Pal RB. Study of fungal and bacterial infections of the diabetic foot. Indian J Pathol Microbiol 2002; 45(1): 15-22.
    26. Buxton PK, Milne LJ, Prescott RJ, et al. The prevalence of dermatophyte infection in well-controlled diabetics and the response to Trichophyton antigen. Br J Dermatol 1996; 134(5): 900-903. Go to original source...
    27. Robbins JM. Treatment of onychomycosis in the diabetic patient population. J Diab Compl 2003; 17: 98-104. Go to original source... Go to PubMed...
    28. Fejfarová V, Skořepová M, Jirkovská A. Diagnostika a léčba mykotických infekcí. HPB Bulletin 2006; 14(4): 147-150.
    29. Falanga V, Oian SV, Danielpour D, et al. Hypoxia upregulates synthesis of TGF beta 1 by human fibroblasts. J Invest Dermatol 1991; 97: 634-637. Go to original source... Go to PubMed...
    30. Schramm JC, Dinh T, Veves A. Microvascular changes in the diabetic foot. Int J Low Extrem Wounds 2006; 5(3): 149-159. Go to original source... Go to PubMed...
    31. Biscetti F, Straface G, Pitocco D, et al. Peroxisome proliferator-activated receptors and angiogenesis. Nutr Metab Cardiovasc Dis 2009, 19(11): 751-759. Go to original source... Go to PubMed...
    32. Idris I, Game F, Jeffcoate W. Does close glycaemic control promote healing in diabetic foot ulcers? Report of feasibility study. Diabet Med 2005; 22: 1060-1063. Go to original source... Go to PubMed...
    33. Hoogwerf BJ. Postoperative management of the diabetic patient. Med Clin North Am 2001; 85(5): 1213-1228. Go to original source... Go to PubMed...
    34. Lilley SH, Levine GI. Management of hospitalized patiens with type 2 diabetes mellitus. Am Fam Physician 1998; 57(5): 1079-1088. Go to PubMed...
    35. Reiber GE. Epidemiology and health care cost of diabetic foot problems. In Veves A, Giurini JM, LoGerfo FW. The diabetic foot. Boston: Munana Press, 2002: 35-58.
    36. Weringer EJ, Kelso JM, Tamai IY, et al. The effect of antisera to insulin, 2-deoxyglucose-induced hyperglycaemia, and starvation on wound healing in normal mice. Diabetes 1981; 30: 407-410. Go to original source... Go to PubMed...
    37. Smiley DD, Umpierrez GE. Perioperative glucose control in the diabetic or nondiabetic patient. South Med J 2006; 99(6): 580-589. Go to original source... Go to PubMed...
    38. Pozzilli P, Leslie RDG. Infections and Diabetes: Mechanisms and Prospects for Prevention. Diabetic Medicine 1994; 11: 935-941. Go to original source... Go to PubMed...
    39. Bessman AN, Sapico FL. Infections in Diabetic Patients: The Role of Immune Dysfunction and Pathogen Virulence Factors. J Diab Compl 1992; 6: 258-262. Go to original source... Go to PubMed...
    40. Marhoffer W, Stein M, Maeser E, et al. Impairment of Polymorphonuclear Leukocyte Function and Metabolic Control of Diabetes. Diabetes Care 1992; 15: 256-260. Go to original source... Go to PubMed...
    41. Boland OM, Blackwell CC, Clarke BF, et al. Effects of ponalrestat, an aldose reductase inhibitor, on neutrophil killing of Escherichia coli and autonomic function in patients with diabetes mellitus. Diabetes 1993; 42(2): 336-340. Go to original source... Go to PubMed...
    42. Llorente L, De La Fuente H, Richaud-Patin Y, et al. Innate immune response mechanisms in non-insulin dependent diabetes mellitus patients assessed by flow cytoenzymology. Immunol Lett 2000; 74(3): 239-244. Go to original source... Go to PubMed...
    43. Delamaire M, Magendre D, Moreno M, et al. Impaired leukocytes functions in diabetic patients. Diabetic Medicine 1997; 14: 29-34. Go to original source... Go to PubMed...
    44. Wierusz-Wysocka B, Wysocki H, Siekierka H, et al. Evidence of polymorphonuclear neutrophils (PMN) activation in patients with insulin dependent diabetes mellitus. J Leukoc Biol 1987; 42: 519-523. Go to original source... Go to PubMed...
    45. Grzybowski J, Janiak MK, Oidak E, et al. New cytokine dressings: II. Stimulation of oxidative burst in leukocytes in vitro and reduction of viable bacteria within an infected wound. Int J Pharm 1999; 184: 179-184. Go to original source... Go to PubMed...
    46. Shalekoff S, Tiemessen CT, Gray CM, Martin DJ. Depressed phagocytosis and oxidative burst in polymorphonuclear leukocytes from individuals with pulmonary tuberculosis with or without human immunodeficiency virus type 1 infection. Clin Diagn Lab Immunol 1998; 5: 41-44. Go to original source... Go to PubMed...
    47. Koarada S, Wu Y. Olshansky G, Ridgway WM. Increased nonobese diabetic Th1:Th2 (IFN -gamma: IL-4) ratio is CD4+ T cell intrinsic and independent of APC genetic background. J Immunol 2002; 169(11): 6580-6587. Go to original source... Go to PubMed...
    48. Eneroth M, Larsson J, Oscarsson C, et al. Nutritional supplementation for diabetic foot ulcers: the first RCT. J Wound Care 2004; 13(6): 230-234. Go to original source... Go to PubMed...
    49. Rohn RD, Pleba P, Jenkins LL. Magnesium, zinc and copper in plasma and blood cellular components in children with IDDM. Clin Chim Acta 1993; 215(1): 21-28. Go to original source... Go to PubMed...
    50. Fejfarová V, Jirkovská A, Kazdová L, et al. Certain vitamins and elements with a relation to immune system in patients with diabetes mellitus (in czech). DMEV 2003; 6(1): 23-29.
    51. Djurhuus MS, Klitgaard NA, Pedersen KK, et al. Magnesium reduces insulin-stimulated glucose uptake and serum lipid concentrations in type 1 diabetes. Metabolism 2001; 50: 1409-1417. Go to original source... Go to PubMed...
    52. Karahan SC, Deger O, Orem A, et al. The effects of impaired trace elements status on polymorphonuclear leukocyte activation in the development of vascular complication in type 2 diabetes mellitus. Clin Chem Lab Med 2001; 39: 109-115. Go to original source... Go to PubMed...
    53. Barker AR, Rosson GD, Delon AL. Wound healing in Denerved Tissue. Ann Plast Surg 2006, 57(3): 339-342. Go to original source... Go to PubMed...

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