Interní Med. 2010; 12(7-8): 357-360

Mineral and bone disorder in chronic kidney disease (MBD-CKD)

MUDr.Kamil Žamboch¹, MUDr.Jana Zahálková, Ph.D.^1,2, MUDr.Zdenka Kosatíková¹

¹ III. interní klinika FN a LF UP, Olomouc

² Středomoravská nemocniční, a. s., člen skupiny Agel, Nemocnice Šternberk

Mineral and bone disorder in chronic kidney disease (MBD-CKD) is defined by the presence of one or more of the three components: renal

osteopathy, abnormal metabolism of calcium, phosphorus and parathyroid hormone, and vascular calcifications. Hyperphosphataemia,

elevated parathormon levels and calcitriol deficiency are independently associated with increased mortality. The most common type in

renal osteopathy is the mixed bone disease, occurring in up to 80 % of dialysis patiens, which is a combination of fibrous osteodystrophy

and osteomalacia. Vascular component of CKD-MBD is significant for its close relationship to cardiovascular complications.

Keywords: renal osteopathy, vascular calcifications, hyperphosphataemia, mineral and bone disorder in chronic kidney disease

Published: August 12, 2010  Show citation