Interní Med. 2001; 3(11): 538-540

Přípravek Plavix (clopidogrel) - farmakologický profil a klinické zkušenosti

MUDr. Petr Janský
Interní klinika fakultní nemocnice Motol a 2. lékařské fakulty Univerzity Karlovy v Praze

Published: December 31, 2001  Show citation

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Janský P. Přípravek Plavix (clopidogrel) - farmakologický profil a klinické zkušenosti. Interní Med. 2001;3(11):538-540.

Farmakodynamické vlastnosti

Clopidogrel (Plavix) je nový antitrombotický lék ze skupiny thienopyridinů. Strukturálně je proto podobný ticlopidinu. Aktivní metabolit clopidogrelu se ireverzibilně váže na receptor pro ADP na povrchové membráně trombocytů. Tím nedochází k ADP dependentní aktivaci glykoproteinu GP IIb/IIIa a k vazbě fibrinogenu na tento receptor. Clopidogrel tedy uvedeným mechanizmem brání ADP indukované agregaci krevních destiček...

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