Interní Med. 2002; 4(3): 123-125

Digoxin a jeho užití na počátku dvacátého prvního století

MUDr. Pavel Sedloň, MUDr. Ilja Kotík
I. interní odd. s JIP, Ústřední vojenská nemocnice Praha

Keywords: Digoxin, Digitalis, Foxglove, History of medicine, Clinically controlled trials, Indications, Contraindications.

Published: December 31, 2002  Show citation

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Sedloň P, Kotík I. Digoxin a jeho užití na počátku dvacátého prvního století. Interní Med. 2002;4(3):123-125.

Digoxin je jedním z nejstarších užívaných léčiv v kardiologii a své místo v léčbě srdečních onemocnění si zachoval dodnes. Jeho použití je vhodné u nemocných se srdečním selháním s fibrilací síní, ale i u nemocných se sinusovým rytmem. Dle závěrů velké, kontrolované, randomizované studie DIG nesnižuje, ale ani nezvyšuje mortalitu, významně zlepšuje kvalitu života a snižuje počet nutných hospitalizací. Použití digoxinu jako antiarytmika je omezeno na kontrolu srdeční frekvence u některých nemocných s fibrilací síní. V jiných indikacích se náprstníkové glykosidy v současnosti nepoužívají.

Digoxin and its use at the begining of the twenty-first century

Digoxin is one of the oldest used medicaments in cardiology, and it has still retained its place in the treatment of heart disease. It can be used for patients with heart failure and atrial fibrillation as well as for patients with sinus rythm. According to the conclusions of a large randomised, placebo-controlled study digoxin neither decreases nor increases mortality, but greatly improves the quality of life and lowers the number of necessary hospitalizations. The use of digoxin as an antiarrythmic is for the strict control of the heart rate of patients with atrial fibrillation. At present no other indications for the use of the foxglove glycosides are indicated.

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