Interní Med. 2002; 4(6): 269-272

TIPS v léčbě portální hypertenze

MUDr. Jaromír Petrtýl CSc, doc. MUDr. Radan Brůha CSc
IV. interní klinika VFN a 1. LF UK, Praha

Keywords: portal hypertension, transjugular intrahepatic portosystemic shunt # TIPS, haemorrhage from esophageal varices.

Published: December 31, 2002  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Petrtýl J, Brůha R. TIPS v léčbě portální hypertenze. Interní Med. 2002;4(6):269-272.

Portální hypertenze je stále závažnou komplikací zejména pokročilých jaterních onemocnění. Komplikace portální hypertenze a to zejména krvácení z jícnových varixů je bezprostředně život ohrožující akutní stav. Transjugulární intrahepatální portosystémový zkrat (TIPS) je novou metodou, která vytváří portosystémový zkrat katetrizační technikou. Ve svých důsledcích vede ke snížení portálního tlaku a tedy k zástavě krvácení do zažívacího traktu, resp. snižuje riziko recidivy krvácení zejména u nemocných s portální hypertenzí na podkladě závažného jaterního postižení. TIPS je tedy indikován v léčbě akutního krvácení a v sekundární prevenci krvácení z jícnových varixů, je však využíván i v léčbě dalších komplikací portální hypertenze.

TIPS IN THERAPY OF PORTAL HYPERTENSION

Portal hypertension is a major sequelae to severe liver disease. The complications of portal hypertension, which are mainly haemorrhage from esophageal varices, can be of an acute life-threatening form. Transjugular intrahepatic portosystemic shunt (TIPS) represents a new technique which can create a portosystemic shunt via a catheter. The outcome of this procedure is a decreased portal pressure, which leads to the cessation of gastrointestinal bleeding. In patients with portal hypertension in the advanced stages of liver disease, the risk of recurrent bleeding is thus diminished. TIPS is indicated in the treatment of acute bleeding and in the secondary prevention of recurrent variceal haemorrhage and could also be used in the management of other complications of portal hypertension.

Download citation

References

  1. Sanyal AJ, Purdum PP, Luketic VA, et al. Bleeding gastroesophageal varices. Semin. Liver Dis 1993: 13; 1407-1413. Go to original source... Go to PubMed...
  2. Levacher S, Letoumelin P, Pateron D, et al. Early administration of terlipressin plus glyceryl trinitrate to control active upper gastrointestinal bleeding in cirrhotic patients. Lancet 1995: 346: 865-868. Go to original source... Go to PubMed...
  3. Garcia-Tsao G, Groszmann RJ, Fisher RL, et al. Portal pressure of gastroesophangeal varices bleeding. Hepatology 1985: 5: 419-424. Go to original source... Go to PubMed...
  4. Rösch J, Hanafee WN, Snow H. Transjugular portal venography and radiologic portocaval shunt: an experimental study. Radiology 1969: 92: 1112-1114. Go to original source... Go to PubMed...
  5. Richter GM, Palmaz JC, Noldge G, et al. The transjugular intrahepatic portosystemic stent-shunt (TIPSS): a new nonoperetive, transjugular percutaneous procedure. Radiology 1989: 29: 406-411.
  6. La Berge JM, Ring EJ, Gordon RL, et al. Creation of transjugular intrahepatic portosystemic shunts with the Wallstent endoprosthesis: result in 100 patients. Radiology 1993:187: 413-420. Go to original source... Go to PubMed...
  7. Hůlek P, Krajina A. Indikace k transjugulárnímu intrahepatálnímu zkratu (TIPS). Bulletin HPB 1995; 3: 24-26.
  8. Kauffmann GW, Richter GM. Transjugular intrahepatic portosystemic sten-shunt (TIPSS): Technique and indications. Eur Radiol 1999; 9: 685-692. Go to original source... Go to PubMed...
  9. Garcia-Pagan JC, Escorsell MD, Moitinho E, et al. Influence of pharmacological agents on portal hemodynamics: Basis for its use in the treatment of portal hypertension. Semin. Liver Dis. 1999; 19: 427-438. Go to original source... Go to PubMed...
  10. Sahagun G, Benner KG, Saxon R, et al. Outcome of 100 patients after transjugular intrahepatic portosystemic shunt for variceal hemorrhage. Am J Gastoenterol 1997; 92: 1444-1452.
  11. Burroughs AK, Hons ChB, Patch D. Transjugular intrahepatic portosystemic shunt. Semin Liver Dis 1999; 19: 457-473. Go to original source... Go to PubMed...
  12. Rössle M, Haag K, Ochs Am, et al. The transjugular intrahepatic portosystemic stent-shunt procedure for variceal bleeding. N Engl J Med 1994; 330: 165-171. Go to original source... Go to PubMed...
  13. Meddi P, Merli M, Lionetti R, et al. Cost analysis for the prevention of variceal rebleeding: A comparsion between transjugular intrahepatic portosystemic shunt and endoscopic sclerotherapy in a selected group of Italian cirrhotic patients. Hepatology 1999; 29: 1074-1077. Go to original source... Go to PubMed...
  14. Ochs A, Rössle M, Haag K, et al. The transjugular intrahepatic postosystemic stent-shunt procedure for refractory ascites: effect on body weight and Child-Pugh score. Am J Gastroenterol 1998; 93: 1891-1894. Go to original source... Go to PubMed...
  15. Schultz SR, La Berge JM, Gordon RI, et al. Anatomy of the portal vein bifurcation: intra versus extrahepatic location - implication for transjugular intrahepatic portosystemic shunts. J Vasc Intervet Radiol 1994; 5: 457-459. Go to original source... Go to PubMed...
  16. Freedman AM, Sanyal AJ. Complications of transjugular intrahepatic portosystemic shunts. Semin Intervent Radiol 1994; 11: 161-177. Go to original source...
  17. Barton RE, Rosch J, Saxon RR, et al. TIPS: Short and long term results. A survey of 1 750 patients. Semin Intervet Radiol 1995; 12: 364-367. Go to original source...
  18. Richter GM, Noeldge G, Palmaz JC, et al. The transjugular intrahepatic portosystemic stent-shut (TIPS): Results of pilot study. Cardiovasc Intervet Radiol 1990; 13: 200-207. Go to original source... Go to PubMed...
  19. Rössle M, Haag K, Ochs A, et al. The transjugular intrahepatic portosystemic stent-shunt procedure for variceal bleeding. N Engl J Med 1994; 330: 165-171. Go to original source... Go to PubMed...
  20. Sauer P, Benz C, Theilmann L, et al. Transjugular intrahepatic portosystemic stent-shunt (TIPS) vs. endoscopic banding in the prevention of variceal rebleeding: Final results of a rendomised study. Gastroenterology 1998; 114: 1334. Go to original source...




Internal Medicine for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.