Interní Med. 2003; 5(4): 162-164

Vyšetření sentinelové uzliny u maligního melanomu

MUDr. Petr Beneš1, prof. MUDr. Jindřich Macháček CSc1, MUDr. Jan Cincibuch1, MUDr. Karel Cwiertka1, MUDr. Pavel Koranda Ph.D2
1 Onkologická klinika FN a LF UP, Olomouc
2 Klinika nukleární medicíny FN a LF UP v Olomouci

Keywords: sentinel lymph node, malignant melanoma, lymphoscintigraphy.

Published: December 31, 2003  Show citation

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Beneš P, Macháček J, Cincibuch J, Cwiertka K, Koranda P. Vyšetření sentinelové uzliny u maligního melanomu. Interní Med. 2003;5(4):162-164.

Incidence maligního melanomu narůstá, proto je třeba zlepšit prognózu daného onemocnění. Toho lze docílit nejen zlepšením terapeutických možností - imunoterapie a imunochemoterapie, ale také zavedením vyšetřování sentinelové uzliny jako standardního terapeutického postupu. Vyšetření sentinelové uzliny nám pomůže odhalit mikrometastázy, které nelze zjistit běžnými zobrazovacími metodami, a tím přesněji stanovit rozsah onemocnění a upřesnit léčebný postup.

Malignant melanoma - the sentinel lymph node evaluation

The effort to improve prognosis of malignant melanoma focuses not only to modern therapeutic modalities (immunotherapy, immunochemotherapy), but also to the new diagnostic procedure - the sentinel lymph node biopsy. The excision of the sentinel lymph node makes possible to detect micrometastatic nodal dissemination in patiens with clinically negative lymph nodes. The identification of early metastatic spread contributes to accuracy of melanoma staging, which helps to avoid extensive lymphatic dissection possibly associated with severe side-effects.

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References

  1. Cascinelli N, Belli F, Santinami M, Fait V, et al. Sentinel lymph node biopsy in cutaneus melanoma The WHO Melanoma Program Experience. Ann Surg Oncol, 2000; 7: 469-474. Go to original source... Go to PubMed...
  2. Fait V, Žaloudíl J, Pačovský Z. Mapování lymfatik a biopsie sentinelové uzliny - nový přístup k problematice lymfadenektomií. Přehled Rozhl Chir 1995; 8: 425-428.
  3. Johnson JM, Yahanda AM, Sondak VK, et al. Cutaneus melanoma: Role of lympfatic mapping and sentinel node biopsy. Curr Probl Dermatol 2001; 13: 119-122. Go to original source...
  4. Staníček J, Ilievová M, Papírková D. Diagnostika sentinelové uzliny u maligního melanomu metodami nukleární medicíny. Prakt Radiol 1999; 4: 14-15.




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