Interní Med. 2004; 6(4): 184-188

Současná inhalační terapie stabilizované chronické obstrukční plicní nemoci

prof. MUDr. Vladimír Vondra

Keywords: inhalation therapy of COPD, SABA, LABA, combination of drugs.

Published: December 31, 2004  Show citation

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Vondra V. Současná inhalační terapie stabilizované chronické obstrukční plicní nemoci. Interní Med. 2004;6(4):184-188.

prof. MUDr. Vladimír Vondra

Plicní oddělení, Zdravotnické zařízení Praha

Je podán přehled současných znalostí moderní inhalační terapie stabilizované chronické obstrukční plicní nemoci (CHOPN) v souladu se Světovou strategií diagnostiky, léčby a prevence CHOPN, která byla publikována v roce 2001 a aktualizována v roce 2003. Hlavní principy inhalační léčby závisí na druhu inhalovaných léků (suspenze, roztok v tlakové nádobce, prášková forma, roztok pro nebulizaci), tíži CHOPN, spolupráci nemocného a dalších faktorech. Několik druhů inhalovaných léků a jejich dávky jsou v přehledu uvedeny (SABA - krátce působící beta2-adrenergní agonisté, LABA - dlouhodobě působící beta2-adrenergní agonisté, kombinovaná bronchodilatancia, anticholinergika). V podrobné analýze jsou dokumentovány výsledky mezinárodních multicentrických studií, které se týkají dlouhodobého anticholinergika tiotropia, LABA a fixní kombinace inhalačních glukokortikoidů s LABA (Seretide, Symbicort).

Modern inhalation therapy of stable chronic obstructive pulmonary disease

Review of contemporary knowledge of modern inhaled COPD therapy is described in accodrance with Global Strategy of Diagnosis, Management and Prevention of COPD published in 2001 and its updates from 2003. Main principles of inhaled therapy are depending on forms of inhaled drugs (suspension, solution in pressurised bottle, dry powder, solution for nebulization), the severity of COPD, cooperation of the patient and other factors. Several sorts of inhaled drugs and their dosages are mentioned (SABA - Short Acting Beta2-adrenergic Agonists, LABA - Long Acting Beta2-adrenergic Agonists, combined bronchodilators, anticholinergics). The results of international multicentral studies concerning long-therm anticholinergic drug - tiotropium, LABA and fixed combination of inhaled glukocorticoids with LABA (Seretide, Symbicort) are documented in thorough detaliled analysis.

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References

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