Interní Med. 2004; 6(5): 262-264
Syndrom neklidných končetin
- Neurologická klinika 1. LF UK a VFN, Praha
Keywords: restless legs syndrome, patophysiology, diagnosis, treatment.
Published: December 31, 2004 Show citation
Syndrom neklidných končetin (RLS - restless legs syndrome) je definován 4 základními diagnostickými kritérii: (1) nutkáním k pohybu spojeným s nepříjemnými pocity v končetinách, (2) zhoršující se klidem, (3) částečně nebo úplně potlačované pohybem, (4) s maximem výskytu během večera a noci. Patofyziologickým podkladem se zdá být dysfunkce v oblasti dopaminergního systému. K diagnóze postačuje dobrá anamnéza, eventuálně polysomnografické vyšetření či aktigrafie. Léčba spočívá v podávání L-dopy, agonistů dopaminu či opioidů.
Restless legs syndrome
Primary features of restless legs syndrome (RLS) are: (1) an urge to move the legs, usually accompanied by uncomfortable sensations in the legs, (2) begin or worsen during periods of rest or inactivity,(3) partially or totally relieved by movement and (4) worsen in the evening or night than during the day. Dopaminergic system dysfunction is suspected. Diagnosis is established on interviewing the patient and by polysomnography or actigraphy. L-Dopa, dopamine agonists and opioids are most recommended in therapy.
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References
- Allen RP, Earley CJ. Augmentation of the restless legs syndrome with carbidopa/levodopa. Sleep 1996; 19: 205-213.
Go to original source... 
Go to PubMed... - Allen RP, Pichietti D, Hening WA, Trenkwalder C, Walters E, Montplaisi J., the participants in the Restless Legs Syndrome Diagnosis and Epidemiology workshop at the National Institute of Health in collaboration with members of the International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations and epidemilogy. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Medicine 2003; 4: 101-119. Go to original source... Go to PubMed...
- Collado-Seidel V, Kohnen R, Samtleben W, Hillebrand GF, Oertel WH, Trenkwalder C. Clinical and biochemical findings in uremic patients with and without restless legs syndrome. Am J Kidney Dis 1998; 31: 324-328. Go to original source... Go to PubMed...
- Ekbom K. Restless legs: a clinical study. Acta Med Scand Suppl 1945; 158: 1-123.
- Entezari-Taher M, Singleton JR, Jones CR, Meekins G, Petajan JH, Smith AG. Changes in excitability of motor cortical circuitry in primary restless legs syndrome. Neurology 1999; 53: 1201-1205. Go to original source... Go to PubMed...
- Garcia-Borreguero D, Larrosa O, de la Llave Y, Verger K, Masramon X, Hernandez G. Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study. Neurology. 2002; 59: 1573-1579. Go to original source... Go to PubMed...
- Guilleminault C, Cetel M, Philip P. Dopaminergic treatment of restless legs and rebound phenomenon. Neurology 1993; 43: 445. Go to original source... Go to PubMed...
- Hening WA. Restless legs syndrome: a sensimotor dysorder of sleep/wake motor regulation. Curr Neurol Neurosci Rep 2002; 2: 186-196. Go to original source... Go to PubMed...
- Hertz G, Fast A, Feinsilver SH, Albertario CL, Schulman H, Fein AM. Sleep in normal late pregnancy. Sleep 1992; 15: 246-251. Go to original source... Go to PubMed...
- Johnson E. Omnibus sleep in America Poll. Washington: National Sleep Foundation; 2001: 46s.
- Kavey N, Walters AS, Hening W, Gidro-Frank S. Opioid treatment of periodic movements in sleep in patients without restless legs. Neuropeptides. 1998; 11: 181-184. Go to original source... Go to PubMed...
- Lauerma H, Markkula J. Treatment of restless legs syndrome with tramadol: an open study. J Clin Psychiatry 1999; 60: 241-244. Go to original source... Go to PubMed...
- Phillips B, Young T, Finn L, Asher K, Hening WA, Purvis C. Epidemiology of restless legs symptoms in adults. Arch Intern Med 2000; 160: 2137-2141. Go to original source... Go to PubMed...
- Saletu M, Anderer P, Saletu-Zyhlarz G, Prause W, Semler B, Zoghlami A, Gruber G, Hauer C, Saletu B. Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo-controlled sleep laboratory studies with clonazepame. Eur Neuropsychopharmacol. 2001; 11: 153-161. Go to original source... Go to PubMed...
- Sun ER, Chen CA, Ho G, Earley CJ, Allen RP. Iron and the restless legs syndrome. Sleep 1998; 1: 371-377. Go to original source...
- Turjanski N, Lees AJ, Brooks DJ. Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies. Neurology 1999; 52: 932-937. Go to original source... Go to PubMed...
- Ulfberg J, Nystrom B, Carter N, Edling C. Prevalence of Restless Legs Syndrome among males aged 18-64 ys. An association with somatic disease and neuropsychiatric symptoms. Mov Disord 2001; 16: 1159-1163. Go to original source... Go to PubMed...
- Walters AS, Wagner ML, Hening WA, Grasing K, Mills R, Chokroverty S, Kavey N. Succesfull treatment of the idiopatic restless legs syndrome in a randomized double-blind trial of oxycodone versus placebo. Sleep 1993; 16: 327-332. Go to original source... Go to PubMed...
- Walters AS. Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord 1995; 10: 634-642. Go to original source... Go to PubMed...
- Willis T. The London practice of physick. London: Bassett, Dring, Harper, and Crook; 1692.
- Zucconi M, Coccagna G, Petronelli R, Gerardi R, Mondini S, Cirignotta F. Nocturnal myoclonus in restless legs syndrome effect of carbamazepine treatment. Funct Neurol. 1989; 4: 263-271.