Interní Med. 2004; 6(12): 603-605

Akné

MUDr. Karel Kočí CSc
Privátní andrologická ordinace Andromeda

Keywords: erectile dysfunction, peroral treatment, PDE5 inhibitors, sildenafil, tadalafil # vardenafil.

Published: December 31, 2004  Show citation

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Kočí K. Akné. Interní Med. 2004;6(12):603-605.

Erektilní dysfunkce (ED) je neschopnost dosáhnout, ale také udržet erekci dostatečnou pro uspokojivý pohlavní styk. ED může být prvním klinickým projevem dosud latentního onemocnění. Včasné zjištění příčiny poruchy erekce může odhalit závažné kardiovaskulární onemocnění, diabetes nebo třeba v krajním případě i karcinom prostaty. Podle studie provedené v ČR v r. 2001 trpí ED 54% mužů ve věku 35-65 let, přičemž středně těžkou a těžkou poruchou je postiženo 26% těchto mužů. V 80% případů se jedná o organickou etiologii - nejčastěji jsou vyvolávající příčinou kardiovaskulární choroby, diabetes mellitus či hypertenze.

V současné době dominuje v léčbě ED perorální farmakoterapie léky užívanými jednorázově před koitem - inhibitory fosfodiesterázy typu 5 (PDE5). Ostatní léčebné metody zůstávají vyhrazeny pro relativně malý počet pacientů. Inhibitory PDE5 jsou registrovány v současné době tři - sildenafil (Viagra), tadalafil (Cialis) a vardenafil (Levitra). Vzájemně se některými svými vlastnostmi liší, takže volbou vhodného přípravku lze léčbu individuálně přizpůsobit potřebám každého jednotlivého pacienta.

Erectile dysfunction and its current peroral treatment

Erectile dysfunction (ED) is the inability to achieve and/or maintain erection sufficient for the satisfactory coitus. ED can be the first symptom of the latent disease so far. The early recognition of the cause of erection failure can discover serious cardiovascular disease, diabetes mellitus or (in the extreme case) even prostate cancer. 54 % of men in the age 35-65 are suffering ED, whereas 26 % of these men are involved with moderate and severe malfunction by the study conducted in Czech Republic in the year 2001. In 80 % of cases the etiology is organic - the most frequent causes are cardiovascular diseases, diabetes mellitus or hypertension.

Peroral farmacotherapy using single dose tablets before the coitus - phosphodiesterase type 5 inhibitors (PDE5) - is currently dominating in ED treatment. Other therapeutical methods are reserved for relatively small number of patients. There are three PDE5 inhibitors currently registered - sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra). They differ in some features, so that the treatment can be individually optimised to every single patient by the choice of the proper drug.

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References

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  2. Eardley I, Ahuja S, Denne J, et al. Time distribution of sexual intercourse attempts after taking tadalafil or placebo. International Journal of Impotence Research 15. 2003; (suppl. 6): PS-3-5.
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