Interní Med. 2005; 7(3): 131-134

Nephrotic syndrome

MUDr. Romana Ryšavá CSc¹, doc. MUDr. Vladimír Tesař DrSc², doc. MUDr. Miroslav Merta CSc²

¹ Klinika nefrologie 1. LF UK a VFN, Praha

² I. interní klinika 1. LF UK a VFN Praha

The review about epidemiology, structural changes in glomeruli, diagnosis, differential diagnosis and therapeutic possibilities in nephrotic syndrome is given. Increased glomerular permeability of the glomerular capillary wall for macromolecules caused by the changes of the structure of the glomerular basement membrane, or podocytes and slit diaphragm between foot processes of podocytes is the main cause of nephrotic syndrome. Recently new information about podocyte proteins (nephrin, podocin, α-actinin 4) and their functions emerged. A deeper understanding of the pathogenesis of hereditary and immunologically based nephrotic syndrome is warranted for installing a rational management. The work-up in the nephrotic syndrome should involve the assessment of albumin-to-creatinine or protein-to-creatinine ratio. The evaluation of the glomerular disease form an integral part of the diagnostic algorithm of the nephrotic syndrome, which unables to fully profit from the complex management of the nephrotic syndrome, involving symptomatic treatment and the treatment of the glomerular disease.

Keywords: Key words: nephrotic syndrome, proteinuria, nephrin, podocin, slit diaphragm.

Published: January 1, 2006  Show citation