Interní Med. 2005; 7(4): 174-176

Bisoprolol in therapy of chronic heart failure

doc. MUDr. Helena Němcová CSc

II. interní klinika FN u sv. Anny LF MU, Brno

Chronic heart failure is a disorder of heart as a pump. It is accompanied by a number of symptoms resulting from impaired contractility and decreased cardiac output. A number of neurohumoral systems is activated and becomes a target of the treatment. Bisoprolol is a highly selective β1-blocker. Its use in patients with chronic heart failure improves the function of the left ventricle, decreases the heart rate and may influence also a remodelation of the left ventricle. In large randomized trials in patients with chronic heart failure it was shown that therapy with bisoprolol increases the life expectancy, decreases the sudden death rate, total mortality, rehospitalisation rate, and cost of treatment with low prevalence of side effects. That is why bisoprolol should be a standard part of the treatment strategy in patients with chronic heart failure together with ACE inhibitors and diuretics.

Keywords: Key words: chronic heart failure, bisoprolol. life expectatncy, sdecrease of sudden death.

Published: January 1, 2006  Show citation