Interní Med. 2005; 7(7): 360-363

Pancreatic carcinoma 2005 - Current situation in diagnosis and treatment

doc. MUDr. Jan Leffler CSc
Chirurgická klinika UK 2. LF a FN Motol, Praha

Pancreatic carcinoma is one of the most malignant diseases in human and the hope for permanent cure is very small even at present. Despite improved options for, broader experiences with pancreas surgery and improved options of intensive perioperative care within past three decades, there were not any major improvements in prolonging a quality survival in patients with carcinoma of the pancreas.

Keywords: Key words: pancreatic carcinoma, diagnosis, treatment.

Published: January 1, 2006  Show citation

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Leffler J. Pancreatic carcinoma 2005 - Current situation in diagnosis and treatment. Interní Med. 2005;7(7):360-363.
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    References

    1. Aly EAH, Johnson CD. Preoperative biliary drainage before resection in obstructive jaundice. Dig Surg, 2001; 18: 84. Go to original source... Go to PubMed...
    2. American Society for Gastrointestinal Endoscopy: The role of ERCP in diseases of biliary tract and pancreas. Gastrointest Endosc, 1999; 50: 915. Go to original source... Go to PubMed...
    3. Andersen JR, Sorensen SM, Kruse A, et al. Randomized trial of endoscopic endoprothesis versus operative bypass in malignant obstructive jaundice. Gut, 1989; 30, 1132. Go to original source... Go to PubMed...
    4. Ariyama J, Suyama M, Satoh K, et al. Imaging of small pancreatic ductal adenocarcinoma. Pancreas, 1998; 16 (3): 396. Go to original source... Go to PubMed...
    5. Beger HG, Gansauge F, Büchler MW, et al. Intraarterial adjuvant chemotherapy after pancreaticoduodenectomy for pancreatic cancer: Significant reduction in occurrence of liver metastasis. World J Surg, 1999; 23: 946. Go to original source... Go to PubMed...
    6. Beger HG, Poch B, Schwarz M, et al. Pankreaskarzinom: Stellenwert der neoadjuvanten Therapie. Chirurg, 2003; 74: 202. Go to original source... Go to PubMed...
    7. Böttger TC, Junginger T. Factors influencing morbidity and mortality after pancreaticoduodenectomy: Critical analysis of 221 resections. World J Surg, 1999; 23: 164. Go to original source... Go to PubMed...
    8. DiCarlo V, Zerbi A, Bolzano G, et al. Pylorus-preserving pancreaticoduodenectomy versus conventional Whipple operation. World J Surg, 1999; 23: 920. Go to original source... Go to PubMed...
    9. Diehl SL, Lehmann KJ, Gaa J, et al. Wertigkeit von Magnetresonanztomographie (MRT), Magnetresonanz-Cholangiopankreatikographie (MRCP) und endoskopischer retrograder Cholangiopankreatikographie (ERCP) bei der Diagnose von Pankreastumoren. Fortschr Röntgenstr, 1999; 170: 463. Go to original source... Go to PubMed...
    10. Friess H, Kleeff J, Fischer L, et al. Chirurgische Standardtherapie beim Pankreaskarzinom. Chirurg, 2003; 74: 183. Go to original source... Go to PubMed...
    11. Gansauge F, Link KH, Rilinger N, et al. Adjuvante regionale Chemotherapie beim resezierten fortgeschrittenen Pankreascarcinom. Chirurg, 1996; 67: 362. Go to PubMed...
    12. Gouma DJ, van Diijkum EJ, van Geenen RC, et al. Are there indications for paliative resection in pancreatic cancer? World J Surg, 1999; 23: 954. Go to original source... Go to PubMed...
    13. Hanbidge AE. Cancer of the pancreas: the best image for early detection - CT, MRI, PET or US? Can J Gastroenterol, 2002; 16: 101. Go to original source... Go to PubMed...
    14. Harrison LE, Klimstra DS, Brennan MF. Isolated portal vein involvement in pancreatic adenocarcinoma. A contraindication for resection? Ann Surg, 1996; 224: 342. Go to original source... Go to PubMed...
    15. Heslin MJ, Brooks AD, Hochwald SN, et al. A preoperative biliary stent is associated with increased complications after pancreatoduodenectomy. Arch Surg, 1998; 133: 149. Go to original source... Go to PubMed...
    16. Hermanek P, Gospodarowicz MK, et al. (editors): Prognostic factors in cancer. Berlin, Heidelberg, New York, Tokio, Springer-Verlag, 1995. Go to original source...
    17. Hoffman JP, Weese JL, Solin LJ, Engstrom P, et al. A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas. Am J Surg, 1995; 169: 71. Go to original source... Go to PubMed...
    18. Hopt UT, Heydasch U. Chirurgische Relevanz bildgebender Diagnostik bei abdominellen Tumoren - Entscheidungswege beim Pankreas. Chirurg, 1997; 68: 325. Go to original source... Go to PubMed...
    19. Hunt GC., Faigel DO.: Assessment of EUS for diagnosis, staging and determining resectability of pancreatic cancer: a rewiev. Gastrointest Endos, 2002; 55: 232. Go to original source... Go to PubMed...
    20. Ihse I, Andersson R, Axelson J, Hansson L. Kombinationstherapie in der Onkologie bei Pankreastumoren. Chirurg 1998; 69: 366. Go to original source... Go to PubMed...
    21. Ihse I, Axelson J, Dawiskiba S, Hansson L. Pancreatic biopsy: Why? When? How? World J Surg, 1999; 23: 896. Go to original source... Go to PubMed...
    22. Jessup JM, Steele G Jr, Mayer RJ, et al. Neoadjuvant therapy for unresectable pancreatic adenocarcinoma. Arch Surg, 1993; 128: 559. Go to original source... Go to PubMed...
    23. Karlson BM, Ekbom A, Lindgren PG, et al. Abdominal US for diagnosis of pancreatic tumor: a prospective cohort analysis. Radiology, 1999; 213: 107. Go to original source... Go to PubMed...
    24. Koslowsky TC, Wilke J, Voiss W, et al. Chirurgische Palliation beim Pankreascarcinom. Chirurg, 2001; 72: 704. Go to original source... Go to PubMed...
    25. Kokubo M, Nishimura Y, Shibamoto Y, et al. Analysis of the clinical benefit of intraoperative radiotherapy in patiens undergoing macroscopically curative resection for pancreatic cancer. Int J Radiat Oncol Biol Phys, 2000; 48: 1081. Go to original source... Go to PubMed...
    26. Launois B, Stasik Ch, Bardaxoglou E, et al. Who benefits from portal vein resection during pancreaticoduodenectomy for pancreatic cancer? World J Surg, 1999; 23: 926. Go to original source... Go to PubMed...
    27. Leffler J, Polouček P. Poruchy hojení anastomoz na pankreatu. Rozhl Chir, 2001; 8: 432.
    28. Leffler J, Polouček P, Krejčí T. Stenozy terminálního choledochu - chirurgické léčení. Rozhl Chir, 2003; 82, 4: 222. Go to PubMed...
    29. Leffler J. Návrh standardu léčby karcinomu pankreatu. Bulletin HPB, 2002; 10, 1: 20.
    30. Leitlinien zur Therapie des exokrinen Pankreaskarzinoms. Beilage zu den Mitteilungen der Deutschen Gesellschaft für Chirurgie, Heft 5, 1996.
    31. Leung JWC, Bowen-Wright M, Aveling W, et al. Coeliac plexus block with alcohol for relief of upper abdominal pain due to cancer and chronic pancreatitis. Br J Surg, 1983; 70, 730. Go to original source... Go to PubMed...
    32. Lillemoe KD, Cameron JL, Kaufman HS, et al. Chemical splanchniectomy in patients with unresectable pancreatic cancer: A prospective randomized trial. Ann Surg, 1993; 217, 447. Go to original source... Go to PubMed...
    33. Lillemoe KD, Pitt HA. Palliation. Surgical and otherwise. Cancer, 1996; 78: 605. Go to original source...
    34. Martigoni ME, Wagner M, Krahenbühel L, et al. Effect of preoperative biliary drainage on surgical outcome after pancreatoduodenectomy. Am J Surg, 2001; 181: 52. Go to original source... Go to PubMed...
    35. National Cancer Institute: Annula cancer statistics review 1973-1988. NIH publication No 91-2784, 1991, Departement of Health and Human Services, Bethesda, Md.
    36. Neoptolemos JP, Kerr DJ, Beger HG, et al. ESPAC - 1 trial progress report: the European randomized adjuvant study comparing radiochemotherapy, 6 months chemotherapy and combination therapy versus observation in pancreatic cancer. Digestion, 1997; 6: 570. Go to original source... Go to PubMed...
    37. Neoptolemos JP, Stocken DD, Friess H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med, 2004; 350: 1200. Go to original source... Go to PubMed...
    38. Parker SL, Tong T, Bolden S, Wingo PA. Cancer statistics 1995. Cancer, 1996; 46: 5.
    39. Pedrazzoli S, DiCarlo V, Dionigi R, et al. Traditional versus extended lymphadenectomy as sociated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of pancreas. A multicentric, prospective, randomized study. Ann Surg, 1998; 228: 508. Go to original source... Go to PubMed...
    40. Pešková M, Gürlich R. Předoperační biliární drenáž u karcinomu hlavy pankreatu. Rozhl Chir, 2004; 83, 12: 624. Go to PubMed...
    41. Povoski SP, Karpeh MS, Conlon KC, et al. Association of preoperative biliary drainage with postoperative outcome following pancreaticoduodenectomy. Ann Surg, 1999; 230: 131. Go to original source... Go to PubMed...
    42. Rösch T, Braig C, Gain T, et al. Staging of pancreatic and ampullary carcinoma by endoscopic ultrasonography. Gastroenterology, 1992; 102: 188. Go to original source... Go to PubMed...
    43. Saeger HD, Dobrowolski F, Naumann B, et al. Palliative Massnahmen im hepatobiliopankreatischen System. Chirurg, 1999; 70: 1402. Go to original source... Go to PubMed...
    44. Seiler CA, Wagner M, Schiller B, et al. Pylorus preserving or classical Whipple operation in tumors. Initial clinical results of a prospective randomized study. Swiss Surg, 2000; 6: 275. Go to original source... Go to PubMed...
    45. Shepherd HA, Royle G, Ross APR, et al. Endoscopic biliary endoprothesis in the palliation of malignant obstruction of the distal common bile duct: A randomized trial. Br J Surg, 1988; 75: 1166. Go to original source... Go to PubMed...
    46. Schoenberg MH, Gansauge F, Kunz R. Die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie beim duktalen Pankreascarcinom. Chirurg, 1997; 68: 1262. Go to original source... Go to PubMed...
    47. Snady H, Bruckner H, Cooperman A, et al. Survival advantage of combined chemoradiotherapy comparted with resection as the initial treatment of patients with regional pancreatic carcinoma. Cancer, 2000; 89: 314. Go to original source...
    48. Sohn TA, Lillemoe KD, Cameron JL, et al. Surgical palliation of unresectable periampullary adenocarcinoma in the 1990s. J Am Coll Surg, 1999; 188: 658. Go to original source... Go to PubMed...
    49. Trede M. Technik der Duodenopankreatektomie nach Whipple. Chirurg, 1994; 65: 232. Go to PubMed...
    50. Van der Schelling GP, van den Bosch RP, Klinkenbijl JHG, et al. Is there a place for gastroenterostomy in patients with advanced cancer of the head of the pancreas? World J Surg, 1993; 17: 128. Go to original source... Go to PubMed...
    51. Welzel TM, Vick C, Reiser M, et al. Pankreaskarzinom: Präzisierung der Diagnostik zur weiteren Therapieplanung. Chirurg, 2003; 74: 171. Go to original source... Go to PubMed...
    52. Yeo ChJ, Abrams RA, Grochow LB, et. al. Pancreaticoduodenectomy for pancreatic adenocarcinoma: Postoperative chemoradiation improves survival. A prospective, single-institucion experience. Ann Surg, 1997; 5: 621. Go to original source...
    53. Yeo ChJ, Cameron JL, Maher MM, et al. A prospective randomized trial of pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy. Ann Surg, 1995; 4: 580. Go to original source...
    54. Yeo CJ, Cameron JL. Improving results of pancreaticoduodenectomy for pancreatic cancer. World J Surg, 1999; 23: 907. Go to original source... Go to PubMed...
    55. Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. Randomized controlled trial evaluating survival, morbidity and mortality. Ann Surg, 2002; 236: 355. Go to original source... Go to PubMed...
    56. Zerbitt A, Fossati V, Parolini D, et al. Intraoperative radiation therapy adjuvant to resection in the treatment of pancreatic cancer. Cancer, 1994; 73: 2930. Go to original source... Go to PubMed...

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