Interní Med. 2005; 7(9): 384-386
Diabetic nephropathy is the most frequent cause of end-stage renal failure in developed countries and its prevalence is steadily increasing. Patients with diabetic nephropathy are, however, endangered more by their high cardiovascular mortality than by the development of end-stage renal failure. Treatment of hypertension with the target blood pressure lower than 130/85 mm Hg lowers in patients with diabetic nephropathy not only cardiovascular risk, but also the risk of progression of the renal disease. While the renoprotective effect of the angiotensin converting enzyme inhibitors and angiotensin antagonists is well documented, evidence for their higher cardioprotectivity compared to other classes of antihypertensive drugs is rather controversial.
Published: January 1, 2006 Show citation