Interní Med. 2005; 7(10): 444-446

SOLITARY PLASMACYTOMA

MUDr. Jaroslav Bačovský CSc

III. interní klinika FN a LF UP Olomouc

Solitary plasmacytomas are localized malignant tumors arising by local proliferation of plasma cell. They rare and amount to 3 to 5% of all malignant plasmacytoma disorders. The most important feature for the examination of solitary plasmacytoma is a sure diagnosis of the really solitary lesion, because its therapeutic modality differs from that of a generalized disease. Solitary extramedullary plasmacytoma usually displays a local expansive character but show a low tendency to generalization. Solitary extramedullary plasmacytoma occur in the nasopharynx, oropharynx, tonsils, nasal cavity and paranasal sinuses, very rarely in the nodes, subcutis, pleura and testis. Local radiotherapy may lead to a complete cure. Solitary plasmacytoma of bone is more frequent than solitary extramedullary plasmacytoma. Its prognosis is less favorable. There is a high risk of development from solitary plasmacytoma of bone into multiple myeloma in contrast to solitary extramedullary plasmacytoma. It should be examined carefully whether a case is solitary plasmocytoma of bone or multiple myeloma. Solitary plasmacytoma of bone frequently incline to generalization in contrast to solitary extramedullary plasmacytoma. Therapeutic modality depends on clinical manifestations. Treatment of choice is radiotherapy with curative dose of 40–50 GY. The irradiation site is larger that the original size of tumor. Surgery is indicated in case of acute spinal compresion or probatory extirpation of tumor. Chemotherapy is indicated if monoclonal immunoglobulin persists in the serum or urine.

Keywords: Key words: solitary extramedullary plasmacytoma, solitary plasmacytoma of bone.

Published: January 1, 2006  Show citation