Interní Med. 2006; 8(5): 240-243

The antiphospholipid syndrome

MUDr. Alena Buliková, prof. MUDr. Miroslav Penka CSc
Oddělení klinické hematologie, FN Brno

The antiphospholipid syndrome is a clinicopathologic syndrome in which antiphospholipid antibodies (APA) are though to be involved in the development of thrombosis and/or pregnancy complications. The authors present a review of mechanisms by which these autoantibodies promote thrombosis, they introduce a new international consensus statement on an update of the classification criteria for antiphospholipid syndrome including wide spectrum of the clinical manifestations. They also list diagnostic and treatment possibilities.

Keywords: Key words: antiphospholipid syndrome, diagnosis, treatment.

Published: June 1, 2006  Show citation

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Buliková A, Penka M. The antiphospholipid syndrome. Interní Med. 2006;8(5):240-243.
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References

  1. Alacrón-Segovia D, Pérez-Vézquez ME, Villa AR, et al. L Preliminary classification criteria for the antiphospholipid syndrome within systemic lupus erythematosus. Sem Arthr Rheumat 1992; 21: 275-285. Go to original source... Go to PubMed...
  2. Ames PR, Ciampa A, Margaglione M, et al. Bleeding and re-thrombosis in primary antiphospholipid syndrome on oral anticoagulation. An 8-year longitudinal comparison with valve replacement and inherited thrombophilia. Thromb Haemost 2005; 93: 694-699. Go to original source... Go to PubMed...
  3. Buliková A, Némethová D, Penka M, et al. Ovlivňuje přítomosti lupus antikoagulans antikoagulační léčbu u pacientů s antifosfolipidovým syndromem? Transfuze a hematologie dnes 2005; 11: 148-153.
  4. Crowther MA, Ginsberg JS, Math JJM, et al. A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome. N Engl J Med 2003; 349: 1133-1138. Go to original source... Go to PubMed...
  5. Dunn AS, Kaboli P, Halfdanarson T, et al. Do patients followed in anticoagulation clinics for antiphospholipid syndrome meet criteria for the disorder? Throm Haemost 2005; 94: 548-554. Go to original source... Go to PubMed...
  6. Finazzi G, Marchioli R, Brancaccio V, et al. A randomized clinical trial of high-intensity warfarin vs conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS). J Thromb Haemost 2005; 3: 848-853. Go to original source... Go to PubMed...
  7. Galli M, Comfurius P, Maassen C, et al. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 1990: 335: 1544-1547. Go to original source... Go to PubMed...
  8. Galli M, Luciani D, Bertolini G, Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 2003; 101: 1827-1832. Go to original source... Go to PubMed...
  9. Galli M, Luciani D, Bertolini G, Barbui T. Anti-?2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome. Blood 2003; 102: 2717-2722. Go to original source... Go to PubMed...
  10. de Groot PG, Derksen RHWM. Antiphospholipid antibodies: update on detection, pathophysiology and treatment. Curr Opin Hematol. 2004; 11: 165-169. Go to original source... Go to PubMed...
  11. de Groot PG, Derksen RHWM. Pathophysiology of the antiphospholipid syndrome. J Thromb Haemost 2005; 3: 1854-1860. Go to original source... Go to PubMed...
  12. Hughes GRV. Thrombosis, abortion, cerebral disease and the lupus anticoagulant. BMJ 1983; 287: 1088-1091. Go to original source... Go to PubMed...
  13. Khamashta MA. Hughes syndrome: history. In Khamashta (Ed): Hughes Syndrome. London: Springer-Verlag 2000: 3-7. Go to original source...
  14. de Larranga G, Forastiero R, Carreras LO, et al. Acquired hypoprothrombinemia a related to high titres of antiprotein-phospholipid antibodies. Thromb Haemost 1999; 81: 317-318. Go to original source... Go to PubMed...
  15. Levine JS, Branch DW, Rauch JR. The antiphospholipid syndrome. N Engl J Med 2002; 346: 752-763. Go to original source... Go to PubMed...
  16. Matsuura E, Igarashi Y, Fujimoto M, et al. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet 1990; 336: 177-178. Go to original source... Go to PubMed...
  17. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Anti-phospholipid antibodies are directed a complex antigen that includes a lipid-binding inhibitor of coagulation. Proc Natl Acad Sci 1990; 87: 4120-4124. Go to original source... Go to PubMed...
  18. Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4: 295-306. Go to original source... Go to PubMed...
  19. de Moerloose P, Reber G. Antiphospholipid antibodies: do we still need to perform anticardiolipin ELISA assays? J Thromb Haemost 2004; 2: 1071-1073. Go to original source... Go to PubMed...
  20. Naess IA, Christiansen SC, Cannegieter sC, et al. A prospective study of anticardiolipin antibodies as a risk factor foe venous thrombosis in a general population (the HUNT study). J Thromb Haemost 2006; 4: 44-49. Go to original source... Go to PubMed...
  21. Ortel TL. Thrombosis and the antiphospholipid syndrome. Hematology 2005; 462-474. Go to original source... Go to PubMed...
  22. Sanmarco M, Bardin N, Blank M, et al. Heterogenity of anti-?2-glycoprotein I antibodies. Tromb Haemost 2005; 93: 80-87. Go to original source... Go to PubMed...
  23. Wilson WA, Gharavi AE, Koike T, et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome. Arthritis Rheumat 1999; 42: 1309-1311. Go to original source...




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