Interní Med. 2006; 8(7): 352-354

Malignant melanoma - the most severe skin tumor

doc. MUDr. Dagmar Ditrichová CSc, MUDr. Martin Tichý Ph.D
Klinika chorob kožních a pohlavních LF UP a FN Olomouc

Malignant melanoma belongs to the most severe skin tumors with permanently growing incidence. Although it is very well accesible only by aspection from the first stages, approximately 70% of patients come to dermatologist with a vertical tumor thickness bigger than 1 mm, predicting less favourable prognosis. The authors describe basic types of malignant melanoma according to clinical picture and biological behaviour as well as risk factors and options for their modification. Prognostic factors are overviewed. Diagnostic guidelines including differential diagnosis are summarised. Recommendation how to deal with suspicious pigmented skin lesion in clinical practice is presented.

Keywords: Key words: malignant melanoma, clinical forms, risk and prognostic factors, ABCDE rule.

Published: June 1, 2006  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Ditrichová D, Tichý M. Malignant melanoma - the most severe skin tumor. Interní Med. 2006;8(7):352-354.
Download citation

References

  1. Arenberger P. Význam disekce sentinelové uzliny u pacientů s maligním melanomem. Ref výběr z dermatovenerologie 2005; S I/05: 11-15.
  2. Baade PD, Balanda KP, Stanton WR, et al. Community perceptions about the important signs of early melanoma. J Am Acad Dermatol 1997; 36: 33-39. Go to original source... Go to PubMed...
  3. Balch CM, Buzaid AC, Soong SJ, et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 2001; 19: 3635-3648. Go to original source... Go to PubMed...
  4. Braun-Falco O, Plewig G, Wolff HH. Dermatológia a venerológia. Martin: Osveta 2001. 1475 s. Go to original source...
  5. Carlson JA, Ross JS, Slominski A, et al. Molecular diagnostics in melanoma. J Am Acad Dermatol 2005; 52: 743-775. Go to original source... Go to PubMed...
  6. Frey T. Současný stav chirurgické léčby kožního melanomu. Trendy v medicíně 2002; 4: 109-115.
  7. Hunter J, Savin J, Dahl M. Clinical Dermatology. Oxford: Blackwell Publishing 2002: 365 s.
  8. Krajsová I, Vítková I, Šuk J, et al. Význam vyšetření sentinelových uzlin u melanomu: I. Obecný přehled. Čes-slov Derm. 2005; 80: 140-146.
  9. Landi G, Polverelli M, Moscatelli G, et al. Sentinel lymph node biopsy in patiens with primary cutaneous melanoma: study of 455 cases. J Eur Acad Dermatol Venereol 2000; 14: 35-45. Go to original source... Go to PubMed...
  10. Li N, Mangini J, Bhawan J. New prognostic factors of cutaneous melanoma: a review of the literature. J Cutan Pathol 2002; 29: 324-340. Go to original source... Go to PubMed...
  11. Lomuto M, Calabrese P, Guinani A. Prognostic signs in melanoma: state of the art. J Eur Acad Dermatol Venereol 2004; 18: 291-300. Go to original source... Go to PubMed...
  12. Pizinger K. Moderní přístup k včasné diagnostice pigmentových útvarů na kůži. Ref. výběr z dermatovenerologie 2005; S I/05: 4-6.
  13. Sagebiel RW. Melanocytic nevi in histologic association with primary cutaneous melanoma of superficial spreading and nodular types: effect of tumor thickness. J Invest Dermatol 1993; 100: 322-325. Go to original source...
  14. Weedon D. Skin Pathology. Edinburg: Churchill Livingstone 2002: 1157 s.
  15. Zitelli JA, Brown CD, Hanusa BH. Surgical margins for excision of primary cutaneous melanoma. J Am Acad Dermatol 1997; 37: 422-429. Go to original source... Go to PubMed...




Internal Medicine for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.