Interní Med. 2006; 8(10): 423-426

Sjögren‘s syndrome

MUDr. Hana Ciferská¹, doc. MUDr. Pavel Horák CSc¹, MUDr. Zuzana Heřmanová², MUDr. Marta Ordeltová², doc. MUDr. Josef Zadražil CSc¹

¹ III. interní klinika FN a LF UP Olomouc

² Oddělení klinické imunologie, FN a UP Olomouc

Sjögren‘s syndrome (SS) is chronic, autoimmune and inflammatory disease with predominant affection of exocrine glands, but also extragrandular manifestations are common occurrence. There are two forms of SS primary and secondary. Secondary SS is connected to presence of other autoimmune disease (rheumatoid arthritis, systemic lupus erythematosus etc.) For this disease is typical production of specific auto antibodies anti-SS-A (anti-Ro) and anti-SS-B (anti-La) and lymphocytary infiltration of exocrine glands. The treatment of SS is mainly symptomatic in the patients without organ manifestation. If the organ manifestation is present, the immunosuppressive therapy is prescribed. The patients with SS have higher risk of occurrence of non-Hodgkin lymphomas.

Keywords: Key words: Sjögren‘s syndrome, anti-SS-A (Ro), anti-SS-B (La), exocrine secretion, autoimmune disease.

Published: February 1, 2007  Show citation