Interní Med. 2007; 9(12): 552-554

Hypertriglyceridemic waist and cardiovascular risk

MUDr. Michal Vrablík Ph.D
III. interní klinika VFN a 1. LF UK, Praha

Cardiovascular diseases have multifactorial etiology. There is no single dominant risk factor that is responsible for most of its prevalence. That is the reason why combined markers are being searched for, which would enable a more precise estimation of risk of atherosclerosis and its complications. One of them is so called hypertriglyceridemic waist. It is a current phenotype characterized by increased waist circumference and fasting triglycerides over 2 mmol/l. Hypertriglyceridemic waist is a marker of metabolic lipid and sugar disturbances and reflects very well pathological changes of postprandial metabolism. In clinical studies hypertriglyceridemic waist turned up to be a useful additional parameter for evaluation of risk of atherosclerotic complications and risk of diabetes mellitus which prevalence is in this phenotype significantly increased. Because of its simplicity and cost-effectiveness hyperglyceridemic waist is an ideal parameter for precision of estimation of cardiovascular complications and a suitable marker in treatment strategy selection.

Keywords: hypertriglyceridemic waist, hyperinzulinemia, apolipoprotein B, waist circumference, cardiovascular risk, risk of diabetes mellitus

Published: January 20, 2008  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Vrablík M. Hypertriglyceridemic waist and cardiovascular risk. Interní Med. 2007;9(12):552-554.
Download citation

References

  1. Alberti KGMM, Zimmet P, Shaw J. The metabolic syndrome - new worlwide definition. Lancet 2005; 366: 1059-1062. Go to original source... Go to PubMed...
  2. Assmann G, Cullen P, Schulte H. Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study. Circulation 2002; 105: 310-315. Go to original source... Go to PubMed...
  3. Blackburn P, Lamarche B, Couillard C, et al. Postprandial hyperlipidemia: another correlate of the, ,hypertriglyceridemic waist" phenotype in men. Atherosclerosis 2003; 171: 327-336. Go to original source... Go to PubMed...
  4. Conroy R, Pyorala K, Fitzgerald A, et al. Prediction of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 2003; 24: 987-1003. Go to original source... Go to PubMed...
  5. Češka R, Vrablík M, Vrablíková K, Králíková E. Hyperlipoproteinémie a dyslipoproteinémie. Causa Subita 2004, 6: 250.
  6. Grundy SM, Cleeman JI, Merz CN, et al. Coordinating committee of the national cholesterole education program. Implications of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines. Arterioscler Thromb Vasc Biol 2004; 24: e149-161. Go to original source... Go to PubMed...
  7. LaMarche B, Tchernof A, Muriege P, et al. Fasting insulin, and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease. JAMA 1998; 279: 1955-1961. Go to original source... Go to PubMed...
  8. Lemieux I, Pascot A, Couillard C, et al. Hypertriglyceridemic waist. A marker of the atherogenic metabolic triad (hyperinsulinemia, hyperapolipoprotein B, small dense LDL) in men? Circulation 2000; 102: 179-184. Go to original source... Go to PubMed...
  9. Patsch JR, Miesenbock G, Hopferwieser T, et al. Relation of triglyceride metabolism and coronary artery disease. Studies in postprandial state. Arterioscler Tromb 1992; 12: 1336-1345. Go to original source... Go to PubMed...
  10. Pouliot MC, Despres JP, Naderu A, et al. Visceral obesity in men: associations with glucose tolerance, plasma insulin and lipoprotein levels. Diabetes 1992; 41: 826-834. Go to original source... Go to PubMed...
  11. Senechal M, Lemieux I, Beucler I, et al. Features of the metabolic syndrome of, ,Hypertriglyceridemic waist" and transplant coronary artery disease. J Heart Lung Transplant 2005; 24: 819-826. Go to original source... Go to PubMed...
  12. Tchernof A, Lamarche B, Prud´Homme D, et al. The dense LDL phenotype: associations with plasma lipopprotein levels, visceral obesity and hyperinsulinemia in men. Diabetes Care, 1994; 119: 629-637. Go to original source...
  13. Zdravotnická ročenka České republiky za rok 2004. ÚZIS Praha, 2005: 270.




Internal Medicine for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.