Interní Med. 2008; 10(2): 50-53

The role of thiazolidindiones in the treatment of type 2 diabetes

prof. MUDr. Jaroslav Rybka DrSc^1,2

¹ Diabetologické centrum Baťovy nemocnice Zlín

² Interní klinika, Krajská nemocnice T. Bati a.s., Zlín

Thiazolidindiones, glitazones have a significant effect on the metabolism of carbohydrates as well as cardiovascular risk factors. In addition, they exert a beneficial effect on the development of atherosclerotic changes in patients with diabetes and may have a protective effect on the function of pancreatic cells. Glitazone indication are being further specified, and particular attention is being paid to any adverse effects and compromised liver function, weight increase, risk of bone fractures and fluid retention. The author pays special attention to possibly higher risk of myocardial infarction with the use of rosiglitazone and points out the possibility of cardiac failure with the use of glitazone therapy. For the time being, however, there is no reason to change the position of TZDs within the algorhythm of oral drug therapy in the treatment of type 2 diabetes.

Keywords: thiazolidindiones, glitazones, indication, adverse effect, fluid retention, heart failure, bone fractures, weight increase, risk of IM, therapy algorythm

Published: May 1, 2008  Show citation