Interní Med. 2008; 10(7): 336-339

Acquired inhibitors of blood coagulation

MUDr. Alena Buliková Ph.D, MUDr. Petr Smejkal, RNDr. Jiřina Zavřelová, MUDr. Gabriela Chlupová, prof. MUDr. Miroslav Penka CSc
Oddělení klinické hematologie, FN Brno

Acquired inhibitors of coagulation are rare autoimmune disorders caused by auto antibodies to haemostasis factors. They are mostly accompanied by bleeding symptoms, but rarely clinical manifestation is asymptomatic or thrombotic. Authors focus to clinical symptoms, diagnosis and therapy possibilities of specific states. These disorders are mentioned here with aim to guarantee fast diagnose and therapy in specialised centres for haemostasis diseases.

Keywords: Key words: acquired haemostasis inhibitors, bleeding, thrombosis, therapy.

Published: October 1, 2008  Show citation

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Buliková A, Smejkal P, Zavřelová J, Chlupová G, Penka M. Acquired inhibitors of blood coagulation. Interní Med. 2008;10(7):336-339.
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    References

    1. Abshire T, Kenet G. Recombinant factor VIIa: rewiew of efficacy, dosing regimens and safety in patients with congenital and acquired factor FVIII or IX inhibitors. J Thromb Haemost 2004; 2: 899-909. Go to original source... Go to PubMed...
    2. Ajzner E, Balogh I, Haramura G, et al. Anti-factor V auto-antibody in the plasma and platelets of a patient with repeated gastrointestinal bleeding. J Thromb Haemost 2002; 1: 943-949. Go to original source... Go to PubMed...
    3. Carroll JF, Moskowitz KA, Rdwards NM, Hickley TJ. Immunologic assessment of patients treated with Bovine fibrin as a hemostatic agent. Thromb Haemost 1996; 76: 925-931. Go to original source... Go to PubMed...
    4. Collins PW, Hirsh S, Baglin TP, et al. Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Hemophilia Centre Doctor´s Organisation. Blood 2007; 109: 1870-1877. Go to original source... Go to PubMed...
    5. Collins PW. Treatment of acquired hemophilia A. J Thromb Haemost 2007; 5: 893-900. Go to original source... Go to PubMed...
    6. Delgado J, Jimenez-Yuste V, Hernandez-Navarro F, Villar A. Acquired haemophilia: review and meta-analysis focused on therapy and prognostic factors. Br J Haematol 2003; 121: 21-35. Go to original source... Go to PubMed...
    7. Franchini M, Veneri D, Lippi G, Stenner R. The efficacy of rituximab in the treatment of inhibitor - associated hemostatic disorders. Thromb Haemost 2006; 96: 119-125. Go to original source... Go to PubMed...
    8. Giangrande P. Acquired hemophilia. In Treatment of hemophilia 2005, 38; www.wfh.org.
    9. Hay CHRM, Collins PW, Keeling DM, Liesner R. The diagnostis and management of factor VIII and IX inhibitors: a guideline from the United Kingdom Haemophilia Centre Doctors Organisation Br J Haematol 2006; 133: 591-605. Go to original source... Go to PubMed...
    10. de Larranga G, Forastiero R, Carreras LO, et al. Acquired hypoprothrombinemia a related to high titres of antiprotein-phospholipid antibodies. Thromb Haemost 1999; 81: 317-318. Go to original source... Go to PubMed...
    11. Lillicrap D, Nair SC, Srivastava A, et al. Laboratory issues in bleeding disorders. Hemophilia 2006; 12 (Suppl. 3): 68-75. Go to original source... Go to PubMed...
    12. Lollar P. Pathogenetic antibodies to coagulation factors. Part II. Fibrinogen, prothrombin, thrombin, factor V, factor XI, factor XII, factor XIII, protein C system and von Willebrad factor. J Thromb Haemost 2005; 3: 1385-1391. Go to original source... Go to PubMed...
    13. Kumar S, Pruthi RK, Nichols WL. Acquired von Willebrand disease. Mayo Clin Proc 2002; 77: 181-187. Go to original source...
    14. Ma AD, Carrizosa D. Acquired factor VIII inhibitors: pathophysiology and treatment. Hematology (Am Soc Hematol Educ Program) 2006; 432-437. Go to original source... Go to PubMed...
    15. Nemes L. Pitlik E. New protocol for immune tolerance induction in acquired hemophilia. Haematologica 2000; 85: 64-78. Go to PubMed...
    16. Renault V, Boehlen F, Ozsahin H, et al. Anti-protein S antibodies following a variacella infection: detection, characterisation and influence on thrombin generation. J Tromb Haemost 2005; 3: 1243-1249. Go to original source... Go to PubMed...
    17. Triplett DA. Use of the dilute Russell viper venom time (dRVVT): Its importance and pitfalls. J Autoimmunity 2000; 15: 173-180. Go to original source... Go to PubMed...
    18. Wiwanitkit V. Spectrum of bleeding in acquired factor V inhibitor. A summary of 22 cases. Clin Appl Thromb/Hemost 2006; 12: 485-488. Go to original source... Go to PubMed...
    19. Zeitler H, Ulrich-Merzenich G, Hess L, et al. Treatment of acquired hemophilia by the BonnMalmö protocol: documentation of an in vivo immunomodulation concept. Blood 2005; 105: 2287-2293. Go to original source... Go to PubMed...

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