Interní Med. 2008; 10(10): 456-460

Diabetes mellitus - specificity and complications in elderly

doc. MUDr. Pavel Weber CSc
klinika geriatrie FN, Brno

The fact that diabetes mellitus involves in the 7th decade up to 20% of population and another 20% suffer impaired glucose tolerance causes that it is clinically the most important metabolic disease in elderly. In seniors it is usually DM type 2 (over 75 years up to 95%). Level of glucose may be elevated mildly and usually is asymptomatic, it may be present for many years without being recognized. In elderly even if the level is high, it may cause atypical and nonspecific symptoms. The diagnoses is based on blood sugar evaluation. Acute complications typical for advanced age are severe hypoglycemia (risk of vascular complications) and hyperosmolar nonketoacidotic coma. Late complications will be mainly macrovascular – myocardial infarction, stroke, peripheral vascular disease, and microvascular – retino-, nephropathy and in general the predisposition to infection. The prognosis of DM in elderly varies according the degree of compensation and control of coexistent risk factors of ischemic heart disease (i.e. hypertension, dyslipidemia). The article also reviews some specificities of diabetes mellitus in elderly from the point of view of epidemiology, ethiopathogenesis and clinical picture.

Keywords: Key words: diabetes mellitus, old-age-polymorbidity, epidemiology, etiopathogenesis, specificity and complications.

Published: January 1, 2009  Show citation

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Weber P. Diabetes mellitus - specificity and complications in elderly. Interní Med. 2008;10(10):456-460.
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References

  1. Abate N, Chandalia M. The impact of ethnicity on type 2 diabetes. J Diabetes Complicat 2003; 17: 39-58. Go to original source... Go to PubMed...
  2. Adler A. Obesity and target organ damage: diabetes. Int J Obes 2002; 26 (Suppl 4): S11-S14. Go to original source... Go to PubMed...
  3. American Diabetes Association. Position statement: Hyperglycemic crises in diabetes. Diabetes Care 2004; 27 (suppl. 1): 94. Go to original source... Go to PubMed...
  4. Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis. Epidemiology, Pathophysiology, and Management. JAMA 2002; 287: 2570-2581. Go to original source... Go to PubMed...
  5. Bergman RN, Ader M. Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocr Metab 2000; 11: 351-356. Go to original source... Go to PubMed...
  6. Björntrop P (ed.). International Textbook of Obesity. NY: John Wiley & Sons Ltd. 2001. 558 s.
  7. Boord JB, Graber AL, Christman JW, Powers AC. Practical management of diabetes in critically ill patients. Am J Respir Crit Care Med 2001; 164: 1763-1767. Go to original source... Go to PubMed...
  8. De Mattia G, Laurenti O, Fava D. Diabetic endothelial dysfunction. Effect of free radical scavenging in type 2 diabetic patients. J Diabetes Complicat 2003; 17: 30-35. Go to original source... Go to PubMed...
  9. Eliasson M, Lindahl B, Lundberg V, Stegmayr B. No increase in the prevalence of known diabetes between 1999 in subjects 25-64 years of age in northern Sweden. Diabet Med 2002; 19: 874-880. Go to original source... Go to PubMed...
  10. Ferrannini E. Hyperinsulinemia and insulin resistance. In: Leroith D, Taylor Si, Olefsky JM. (Eds). Diabetes mellitus. A fundamental and clinical text 2nd ed. PA USA: Lippincot Williams&Wilkins. 2000: 991-999.
  11. Forbes A, Elliott T, Tildesley H, Finegood D, Meneilly GS. Alterations in non-insulin-mediated glucose uptake in the elderly patient with diabetes. Diabetes 1998; 47: 1915-1919. Go to original source... Go to PubMed...
  12. Haddock C K, Poston W S C, Dill P L, Foreyt J P and Ericsson M. Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials. Int J Obes 2002; 26: 262-273. Go to original source... Go to PubMed...
  13. Hall JB, Schmidt GA, Wood LDH, Tailor CD (eds). Principles of critical care - 3rd ed. New York: McGraw-Hill, Medical Publishing Division 2005. 192 s.
  14. Harris MI. Summary. In: National Diabetes Data Group; National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes in America. 2nd ed. Bethesda, Md.: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 1995: 1-13. NIH publication 95-1468.
  15. Kahn CR, King GL, Moses AC, Weir GC, Jacobson AM, Smith RJ. Joslin's Diabetes Mellitus, 14th edition. Joslin diabetes center. New York: Lippincott Williams & Wilkins 2005. 1224 s.
  16. Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson JL (eds.). Harrison's Principles of Internal Medicine 16th edition New York: McGraw-Hill Medical Publishing Division 2005. 2680 s.
  17. Kitabchi AE, Umpierrez GE, Murphy MB, Barrett EJ, Kreisberg RA, Malone JI, Wall BM; American Diabetes Association. Management of hyperglycemic crises in patients with diabetes. 2004; 27 Suppl 1: S94-102.
  18. Knowler WC, Barret-Connor EE, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New Engl J Med 2002; 346: 393-403. Go to original source... Go to PubMed...
  19. Kuchler F and Lin B-H. The influence of individual choices and attitudes on adiposity. Int J Obes 2002; 26: 1017-1022. Go to original source... Go to PubMed...
  20. Menon VU, Kumar KV, Gilchrist A, Sugathan TN, Sundaram KR, Nair V, Kumar H. Prevalence of known and undetected diabetes and associated risk factors in central Kerala - ADEPS. Diabetes Res Clin Pract 2006; 74: 289-294. Go to original source... Go to PubMed...
  21. Mohan V. Sandeep S. Deepa B. Shah & Varghese C. Epidemiology of type 2 diabetes: Indian scenario. Indian J Med Res 2007; 125: 217-230.
  22. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS. Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors. JAMA 2003; 289: 76-79. Go to original source... Go to PubMed...
  23. Motta M, Bennati E, Ferlito L, Malaguarnera M. Diabetes mellitus in the elderly: diagnostic features. Arch Gerontol Geriatr 2006; 42: 101-106. Go to original source... Go to PubMed...
  24. Németh F, Koval Š, Zavázalová H, Baník M. (Prešov, Košice, Plzeň). End of life, Bratislava Medical Journal BLL 2007; 108: 239-245.
  25. Németh F, Slivková A. Ultrafiltrácia - alternatívna liečby refraktérnej srdcovej slabosti. Geriatria 2006; 12: 142-145.
  26. Olefsky JM. Prospects for research in diabetes mellitus. JAMA 2001; 285: 628-632. Go to original source... Go to PubMed...
  27. Pickup JC, Williams G, Bridge JS (eds.). Textbook of diabetes. Oxford-London: Blackwell Science Ltd. 2002. 1520 s.
  28. Plutzky J, Viberti G, Haffner S. Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targets. J Diabetes Complicat 2002; 16: 401-415. Go to original source... Go to PubMed...
  29. Reaven GM, Laws A (eds.). Insulin Resistance: the Metabolic Syndrome X. NY: Humana Press 1999: 384 s. Go to original source...
  30. Rössner S. Obesity: the disease of the twenty-first century. Int J Obes 2002; 26 Suppl 4: S2-S4. Go to original source... Go to PubMed...
  31. Sinclair AJ, Finucane P (eds.). Diabetes in old age. 2nd edition. New York: John Wiley & Sons 2001: 274 s. Go to original source...
  32. Soška V. Poruchy metabolizmu lipidů: Diagnostika a terapie. Praha: Grada Publishing 2001: 166 s.
  33. Souček M, Kára T. et al. Klinická patofyziologie hypertenze. Praha: Grada Publishing 2002: 649 s.
  34. Sowers JR, Williams M, Epstein M, Bakris G. Hypertension in patients with diabetes. Strategies for drug therapy to reduce complications. Postgrad Med 2000; 107: 47-54. Go to original source... Go to PubMed...
  35. Stone CK, Humphries R (eds.). Current Emergency Diagnosis & Treatment 5th edition. NY: McGraw-Hill Companies, Inc. 2004: 1168 s.
  36. Tintinalli JE, Kelen GD, Stapczynski JS (eds.). Emergency Medicine: A Comprehensive Study Guide - sixth edition. NY: McGraw-Hill Medical Publishing Division 2004: 2016 s.
  37. Tuomilehto J, Lindstrom J, Eriksson JG, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glugose tolerance. N Engl J Med 2001; 344: 1343-1350. Go to original source... Go to PubMed...
  38. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352: 837-853. Go to original source...
  39. UK Prospective Diabetes Study Group. United Kingdom prospective diabetes study (UKPDS) 13: relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. Br Med J 1995; 310: 83-88. Go to original source... Go to PubMed...
  40. Vinik A, Flemmer M. Diabetes and macrovascular disease. J Diabetes Complicat 2002; 16: 235-245. Go to original source... Go to PubMed...
  41. Yoshino G, Hirano T, Kazumi T. Atherogenic lipoproteins and diabetes mellitus. J Diabetes Complicat 2002; 16: 29-34. Go to original source... Go to PubMed...




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