Interní Med. 2008; 10(10): 478

Jak hodnotit hladinu celkového tyroxinu v těhotenství?

doc. MUDr. Jan Čáp CSc
I. interní klinika Fakultní nemocnice v Hradci Králové

Celkový tyroxin je pro posouzení funkce štítné žlázy v těhotenství nevhodný, protože hodnoty jsou ovlivněny zvýšením vazebné kapacity séra. Rozhodující pro posouzení funkce je hladina tyreostimulačního hormonu (TSH) a tyroxinu volného (free tyroxin fT4). Díky vysoké hladině choriového gonadotropinu jsou normy TSH a fT4 v těhotenství odlišné a závislé na trimestru. I subklinická porucha funkce štítné žlázy má nepříznivý dopad na průběh těhotenství i na plod a je nutno ji léčit.

Keywords: Klíčová slova: těhotenství, celkový tyroxin, volný tyroxin, funkce štítné žlázy, tyreostimulační hormon.

Published: January 1, 2009  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Čáp J. Jak hodnotit hladinu celkového tyroxinu v těhotenství? Interní Med. 2008;10(10):478.
Download citation

References

  1. Dashe JS, Casey BM, Wells CE, et al. Thyroid-stimulating hormone in singleton and twin pregnancy: importance of gestational age-specific reference ranges. Obstet Gynecol 2005; 106(4): 753-757. Go to original source... Go to PubMed...
  2. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 1997; 18(3): 404-433. Go to original source... Go to PubMed...
  3. Gong Y, Hoffman BR. Free thyroxine reference interval in each trimester of pregnancy determined with the Roche Modular E-170 electrochemiluminescent immunoassay. Clin Biochem 2008; 41(10-11): 902-906. Go to original source... Go to PubMed...
  4. Haddow JE, Knight GJ, Palomaki GE, McClain MR, Pulkkinen AJ. The reference range and within-person variability of thyroid stimulating hormone during the first and second trimesters of pregnancy. J Med Screen 2004; 11(4): 170-174. Go to original source... Go to PubMed...
  5. Lambert-Messerlian G, McClain M, Haddow JE, et al. Firstand second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study. Am J Obstet Gynecol 2008; 199(1): 62.e1-6. Go to original source... Go to PubMed...
  6. Sapin R, d'Herbomez M. Free thyroxine measured by equilibrium dialysis and nine immunoassays in sera with various serum thyroxine-binding capacities. Clin Chem 2003; 49(9): 1531-1535. Go to original source... Go to PubMed...




Internal Medicine for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.