Interní Med. 2008; 10(12): 562-566

Drug interactions with can endanger diabetic patients in CR

MUDr. Michal Prokeš
INFOPHARM a.s., Hvožďanská 3, 148 00 Praha 4

Drug interactions are the cause of much trouble to diabetic patients, especially because these people usually take continually more than one drug. In this paper drug interactions of antidiabetics, ACE-inhibitors (ACE-I), angiotensin receptor blockers (ARB) and statins are described. Hyperkalemia caused by ACE-I or ARB is augmented by co-prescription of spironolactone, which is in clinical praxis underestimated. Statins are metabolised by different enzymes P-450, so that their drug interactions are different. For example clarithromycin increase plasma levels of simvastatin, atorvastatin and lovastatin, but not of fluvastatin.

Keywords: Key words: drug interactions, ACE-inhibitors, statins, diabetics.

Published: January 1, 2009  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Prokeš M. Drug interactions with can endanger diabetic patients in CR. Interní Med. 2008;10(12):562-566.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Juurlink DN, et al. Rates of hyperkalemia after publication of the randomized aldactone evaluation study. N Engl J Med 2004; 351: 543-551. Go to original source... Go to PubMed...
    2. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999; 341: 709-717. Go to original source... Go to PubMed...
    3. Wrenger E, et al. Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases. Br Med J 2003; 327: 147-149. Go to original source... Go to PubMed...

    Return to the content


    Internal Medicine for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.