Interní Med. 2009; 11(11): 498-502

New findings of the treatment of osteoporosis

MUDr.Dana Michalská, Ph.D.

Osteocentrum, III. interní klinika, 1. LF UK a VFN Praha

Osteoporotic fractures result from changes in bone mass, architecture and/or quality. In most instances these changes result from an

imbalance between bone resorption and formation during the remodeling cycle. Therapeutic intervention can decrease bone resorption

(anti-resorptives) and/or increase bone formation (anabolics). These interventions are however complicated by a coupling between resorption

and formation in bone remodeling, leading to decreased bone formation in patiens treated with anti-resorptive. The understanding

of the regulary mechanisms of the bone formation and the bone resorption brings new options of the treatment of osteoporosis. The

range of new promising drugs is wide, from innovation of current agents with enhanced effects (SERM, calcitonin), through modulation

of osteoclast metabolism (inhibitors of the cathepsin K, denosumab) and through modulation of transduction procesess in osteoblasts

(Wnt signaling, antibodies against sclerostin).

Keywords: osteoporosis, anti-resorption treatment, inhibitors of the cathepsin K, denosumab, anabolic treatment, PTH, Wnt signaling

Published: May 1, 2010  Show citation