Interní Med. 2009; 11(11): 504-506
In April 2009, a new Czech guideline was issued on diagnosing and treatment of chronic hepatitis B. Therapeutically, the most significant
change is the diversion from using drugs that have the lowest efficacy and are associated with a high risk of developing resistance to
them during treatment (lamivudine, telbivudine, adefovir dipivoxil). Currently, pegylated interferon alpha-2a, tenofovir, and entecavir
are clearly preferred in treatment-naive patients. The combination of pegylated interferon alpha and ribavirin remains the standard
treatment of chronic infection with the hepatitis C virus. Monitoring of viral kinetics at the beginning of antiviral therapy and adjusting
the duration of therapy based on the virological response to treatment are of increasing significance in an attempt to maximize the
therapeutic potential of these drugs.
ribavirin.
Published: May 1, 2010 Show citation