Interní Med. 2009; 11(11): 504-506

Treatment of chronic viral hepatitides in 2009

prof.MUDr.Petr Husa, CSc.
Klinika infekčních chorob LF MU a FN Brno

In April 2009, a new Czech guideline was issued on diagnosing and treatment of chronic hepatitis B. Therapeutically, the most significant

change is the diversion from using drugs that have the lowest efficacy and are associated with a high risk of developing resistance to

them during treatment (lamivudine, telbivudine, adefovir dipivoxil). Currently, pegylated interferon alpha-2a, tenofovir, and entecavir

are clearly preferred in treatment-naive patients. The combination of pegylated interferon alpha and ribavirin remains the standard

treatment of chronic infection with the hepatitis C virus. Monitoring of viral kinetics at the beginning of antiviral therapy and adjusting

the duration of therapy based on the virological response to treatment are of increasing significance in an attempt to maximize the

therapeutic potential of these drugs.

ribavirin.

Keywords: viral hepatitis, pegylated interferon alpha, standard interferon alpha, adefovir dipivoxil, entecavir, telbivudine, tenofovir,

Published: May 1, 2010  Show citation

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Husa P. Treatment of chronic viral hepatitides in 2009. Interní Med. 2009;11(11):504-506.
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References

  1. Urbánek P. Infekce virem hepatitidy C. 1. vyd. Praha: Galén; 2004.
  2. Husa P. Virové hepatitidy. 1. vyd. Praha: Galén; 2005.
  3. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Management of chronic hepatitis B. J Hepatol 2009, 50: 227-242. Go to original source... Go to PubMed...
  4. Husa P, Plíšek S, Šperl J, Urbánek P (koordinátoři), Galský J, Hůlek P, Kümpel P, Němeček V, Volfová M (abecedně). Diagnostika a léčba chronické hepatitidy B. Doporučený postup ČHS a SIL ČLS JEP. Datum vydání doporučení: duben 2009. 1) Prakt Lék 2009; 89: 167-176 2) Klin Mikrobiol Inf Lék 2009; 15: 65-76.
  5. Urbánek P, Husa P, Galský J, Šperl J, (koordinátoři), Kümpel P, Němeček V, Plíšek S, Volfová M (v abecedním pořadí). Standardní diagnostický a terapeutický postup chronické infekce virem hepatitidy C (HCV). Doporučený postup České hepatologické společnosti a Společnosti infekčního lékařství ČLS JEP. Datum vydání doporučení 18. března 2008. Čas Lék Čes 2008; 146: I-XII.




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