Interní Med. 2010; 12(1): 22-25

Management of (resistant) dyslipidaemia

MUDr.Jan Piťha, CSc.

Laboratoř pro výzkum aterosklerózy, Institut klinické a experimentální medicíny, Praha

Successful treatment of dyslipidemias is a cornerstone in prevention of cardiovascular diseases. In high risk patients, especially diabetics

with history of cardiovascular disease, aggressive lowering of all atherogenic lipid components is definitely crucial for their destiny. The

achievement of desired blood lipids is therefore more challenging and demands intensive life style counselling together with judicious

use of higher doses and combinations of lipid lowering drugs, especially statins and fibrates. On the other hand, with increasing number

of patients treated with hypolipemic drugs, increasing doses of mainly statins and in addition the combination of hypolipemics drugs,

more adverse effects are to be expected, together with increased number of patients in whom the achievement of recommended lipid

values will be more challenging. Secondary dyslipidemias and drug interactions should be also taken into consideration. The aim of this

article is to discuss some problems in resistant dyslipidemias with focus on solution of adverse effects of hypolipemic therapy.

Keywords: dyslipidaemia, resistance to treatment, statin intolerance, myopathy

Published: May 1, 2010  Show citation