Interní Med. 2010; 12(4): 191-195

Pregnacy and thyroid gland

prof.MUDr.Václav Zamrazil, DrSc.
Endokrinologický ústav, Subkatedra endokrinologie IPVZ Praha

Pregnancy is connected with necessity to increase function of the thyroid, as thyroid hormones should supply not only pregnant women,

but predominantly fetus. For synthezis of thyroid hormones, increased supply of iodine is necessary. Pregnancy influences diagnosis

of thyroid disorders (increased total thyroxine level, changes of secretio of TSH due to effects of placental hormones) as well as therapy

(increase of iodine supply, increase of supplementary doses of thyroxine etc.). Even minimal changes of thyroid hormones and of iodine

saturation are harmful for optimal development of fetus (esp. its brain) and for course of pregnancy and labor. Screening of thyroid

disorders is pregnancy is still a matter of controversies: it should be performed in the risk groups only, or in all pregnant women?

Keywords: the thyroid, pregnancy, iodine saturation, diagnosis and therapy, screening

Published: May 1, 2010  Show citation

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Zamrazil V. Pregnacy and thyroid gland. Interní Med. 2010;12(4):191-195.
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References

  1. Abalovich M, et al. Clinical practice guideline management of thyroid dysfunction during pregnancy and postpartum and Endocrine Society clinical practice guideline. J. Clin. Endocrinol Metab 2007; 91(S2): 1-47. Go to original source... Go to PubMed...
  2. Fischer DA. Fetal neonatal endocrinology. In DeGroot LJ, Jameson JL, Elseviever, Philadelphia, 2006.
  3. Kaňová N. Onemocnění štítné žlázy a příštitných tělísek v graviditě. In: Stárka L, a kol. Pokroky v endokrinologii. Maxdorf, Praha, 2007.
  4. Límanová Z. Onemocnění štítné žlázy v graviditě. In Límanová Z. Štítná žláza. Galén Praha, 2006.
  5. Parry SP, Strauss JE. Placental hormones. In. DeGroot LJ, Jameson YL. Endocrinology. 5. vyd. Elseviever, Philadelphia, 2006.
  6. Pearce E. Iodine nutrition in the U.S. IDD Newsletter 2006: 2514-2516.
  7. Rusman KD. Controversies surrounding pregnancy, maternal thyroid status and fetal outcome. Thyrvies 2009; 19(4): 323-326. Go to original source...
  8. Bílek R, Čeřovská J. Jod a tyreoidální hormony. Vnitřní Lék. 2006; 52: 881-890.
  9. Costeira MJ, et al. Iodine status of pregnant women and their progeny in the Minho region of Portugal. Thyroid 2009; 19: 157-161. Go to original source... Go to PubMed...
  10. Límanová Z, Jiskra J. Štítná žláza a gravidita. Postgrad. Med. v tisku.
  11. Natl Committee for Iodine Deficiency: Iodine in pregnancy and lactation, Skopje 2008.
  12. Ovelar E, et al. Elimination of IDD and emerging risk of iodine excess in Paraquay. IDD Newsletter 2009; 28: 15-17.
  13. WHO, UNICEF. Reaching optimal iodine nutrition in pregnant and lactating women and young children. IDD Newsletter 2008; 27: 1-3.
  14. WHO Techn. Consultation: Iodine requirements in pregnancy and infancy. IDD Newsletter 2007; 23: 1-2.
  15. Zamrazil V, et al. Hodnocení výsledků jodové profylaxe v České republice. Čas. Lék. čes. 2007; 146: 262-266.
  16. Glinoer D, Ravel J. Gestational hypotyroeinemia and the beneficial effects of early dietary iodine fortification. Thyroid 2009; 10: 1572-1574. Go to original source... Go to PubMed...
  17. Lockwood CM, Grenache DG, Gronowski AM. Serum human chorionic gonadotropin concentration greater than 400 000 IU/L are invarianbly associted with suppresed serum thyrotropin concentration. Thyroid 2009; 19: 863-866. Go to original source... Go to PubMed...
  18. Rinaldi MD, Stagnaro Green AJ. Thyroid disease and pregnancy: degrees of knowledge. Thyroid 2007; 7: 747-751. Go to original source... Go to PubMed...
  19. Abalovich M, et al. Overt and subclinical hypotyroidism complicating pregnancy. Thyroid 2002; 12: 63-68. Go to original source... Go to PubMed...
  20. Hallegreb B, et al. Pregnant women on thyroxine substitution are often dysregulated in early pregnancy. Thyroid 2008; 4: 391-394. Go to original source...
  21. Jameson JL, Weetman AD. Disorders of the thyroid gland s. 2235-2247 in Harrison´s principles of internal medicine, 17. vyd. McGraw-Hill Comp., 2008.
  22. Loh JH, et al. The magnitude of increased levothyroxine requirements in hypothyroid women depends upon etiology of the hypothyroidism. Thyroid 2009; 19: 269-273. Go to original source... Go to PubMed...
  23. Montoro M, et al. Successful outcome of pregnancy in women with hypothyroidism. Ann Intern Med 1989; 94: 31-34. Go to original source... Go to PubMed...
  24. Davies TF. Time for the American thyroid association to lead on thyroid screening in pregnancy. Thyroid 2007; 17: 697-698. Go to original source... Go to PubMed...
  25. Dosin Ch, et al. Screening pregnant women for autoimmune thyroid disease: a cost-effectiveness analysis. Eur. J. Endocrinol 2008; 158: 841-851. Go to original source... Go to PubMed...
  26. Lazarus JH, Premawardhana LD. Screening for thyroid disease in pregnancy. J. Clin. Pathol 2005; 58: 449-452. Go to original source... Go to PubMed...
  27. Límanová Z, Zamrazil V. Má být zaveden screening funkčních tyreoidálních onemocnění u dospělých v České republice? Diabetes Metab. Endocrinol. Výživa 2004; 7: 124-129.
  28. Vaida B, et al. Detection of thyroid dysfunction in early pregnancy: univerzal screening or targeted high risk case finding? J. Clin Endocrinol Metab 2007; 92: 203-209. Go to original source... Go to PubMed...
  29. Glinoer D, et al. Journal of clinical endocrinology and metabolism 1990; 71: 276. Go to original source... Go to PubMed...




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