Interní Med. 2010; 12(9): 414-418

Oxidative stress and its relationship to diabetes compliations

prof.MUDr.Jan Škrha, DrSc.
III. interní klinika 1. LF UK v Praze

Oxidative stress in diabetes is considered at present time as a key cause in development of late complications. It is contemporary binding

element between separate pathogenic pathways participating at development of vascular changes. Hyperglycemia, which is the

main source of accelerated oxidative stress, induces especially in combination with dyslipoproteinemia advanced atherogenesis. Main

associations between oxidative stress and mechanisms leading to vascular wall changes are summarized in this overview. The main goal

is therefore the intensive diabetes therapy as well as the treatment of associated risk factors which may decrease oxidative stress and

slow down development of vascular changes.

Keywords: oxidative stress, diabetes mellitus, pathogenic mechanisms, chronic vascular complications

Published: October 1, 2010  Show citation

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Škrha J. Oxidative stress and its relationship to diabetes compliations. Interní Med. 2010;12(9):414-418.
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