Interní Med. 2010; 12(10): 466-469

Proton pumps inhibitors therapy prescribed by internists and cardiologist at outpatients clinic

prof.MUDr.Milan Lukáš, CSc.^0,2, MUDr.Dana Ďuricová

¹ Klinické a výzkumné centrum pro střevní záněty 1. LF UK a ISCARE, a.s., Praha

² Ústav biochemie a laboratorní diagnostiky 1. LF UK a VFN v Praze

Introduction of proton pump inhibitors (PPIs) into clinical practice meant the significant advance in therapy of acido-peptic disorders.

PPIs are the most important drugs for the therapy of gastro-esophageal reflux diseases, peptic ulcer disease, Helicobacter pylori infection

eradication as well as they are the most powerful prophylactic therapy against NSAIDs gastropathy. PPIs are usually administered

in one morning dose. The treatment with other secretolytic drugs, which increase the intragastric pH level simultaneously with PPIs are

wholy inappopriate. The safety profil based on long-term experience, seems to be very safe. Currently, an interaction between PPIs and

clopidogrel metabolisms which might reduced the efficacy of clopidogrel is under discussion.

Keywords: proton pump inhibitors, gastro-esophageal reflux disease, peptic ulcer, NSAIDs gastropathy

Published: November 15, 2010  Show citation