Interní Med. 2010; 12(10): 516-519

Is metformin only an antidiabetic drug?

prof.MUDr.Jindřiška Perušičová, DrSc.
Interní klinika FN Motol a 2. LF UK Praha

For over fifty years, metformin has been known as an effective antihyperglycaemic drug not associated with weight gain. In recent years,

it has been successfully used in nondiabetic situations as well. Metformin substitutes for the lack of safe anti-obesity medications, is the

drug of choice in women with PCOS and is therapeutically valid in individuals with NASH. The most significant activity of metformin that

has been shown recently is its anti-tumorous effect in a number of cancers.

Keywords: metformin, weight, PCOS, NASH, oncological therapy

Published: November 15, 2010  Show citation

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Perušičová J. Is metformin only an antidiabetic drug? Interní Med. 2010;12(10):516-519.
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References

  1. Green BD, Irwin N, Duffy NA, et al. Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1. Eur J Pharmacol. 2006; 10, 547(1-3): 192-199. Go to original source... Go to PubMed...
  2. Charles MA, Morange P, Eschwege E, et al. Effect of weight change and metformin on fibrinolysis and the von Willebrand factor in obese nondiabetic subjects: the Bigpro1 study. Biguanides and the prevention of the risk of obesity. Diabetes Care 1998; 21(11): 1967-1972. Go to original source... Go to PubMed...
  3. Charles MA, Eschw?ge E, Grandmottet P, et al. Treatment with metformin of non-diabetic men with hypertension, hypertriglyceridaemia and central fat distribution: the BIGPRO 1.2 trial. Diabetes Metab Res Rev. 2000; 16(1): 2-7. Go to original source... Go to PubMed...
  4. Bard JM, Charles MA, Juhan-Vague I, et al. Accumulation of triglyceride-rich lipoprotein in subjects with abdominal obesity: the biguanides and the prevention of the risk of obesity (BIGPRO) 1 study. Arterioscler Thromb Vasc Biol. 2001; 21(3): 407-414. Go to original source... Go to PubMed...
  5. Desilets AR, Dhakal-Karki S, Dunican KC. Role of metformin for weight management in patients without type 2 diabetes. Ann Pharmacother. 2008; 42(6): 817-826. Go to original source... Go to PubMed...
  6. Golay A. Metformin and body weight. International Journal of Obesity, 2008; 32: 61-72. Go to original source... Go to PubMed...
  7. Lim S, Norman R, Clifton P, Noakes M. The effect of comprehensive lifestyle intervention or metformin on obesity in young women. Nutr Metab Cardiovasc Dis. 2010; Feb 15. [Epub ahead of print]. Go to original source... Go to PubMed...
  8. Ibá?ez L, Lopez-Bermejo A, Diaz M, et al. Pubertal metformin therapy to reduce total, visceral, and hepatic adiposity. J Pediatr. 2010; 156(1): 98-102. Go to original source... Go to PubMed...
  9. Rogovik AL, Chanoine JP, Goldman RD. Pharmacotherapy and weight-loss supplements for treatment of paediatric obesity. Drugs 2010; 12, 70(3): 335-346. Go to original source... Go to PubMed...
  10. Kay JP, Alemzadeh R, Langley G, et al. Beneficial effects of metformin in normoglycemic morbidly obese adolescents. Metabolism. 2001; 50(12): 1457-1461. Go to original source... Go to PubMed...
  11. Paulweber B, Valensi P, Lindström J, et al. A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res. 2010; 42(Suppl. 1): S3-36. Go to original source... Go to PubMed...
  12. Otta CF, Wior M, Iraci GS, et al. Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial. Gynecol Endocrinol. 2010; 26(3): 173-178. Go to original source... Go to PubMed...
  13. Cibula D, Stárka L, Vrbíková J. Syndrom polycystických ovarií. Praha: Maxdorf, 2004.
  14. Duvnjak M, Tomasic V, Gomercic M, et al. Therapy of nonalcoholic fatty liver disease: current status. J Physiol Pharmacol. 2009;60 (Suppl. 7): 57-66.
  15. Stein LL, Dong MH, Loomba R. Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status. Adv Ther. 2009; 26(10): 893-907. Go to original source... Go to PubMed...
  16. Lilly M, Godwin M. Treating prediabetes with metformin: systematic review and meta-analysis. Can Fam Physician. 2009; 55(4): 363-369. Go to PubMed...
  17. Landman GW, Kleefstra N, van Hateren KJ, et al. Metformin associated with lower cancer mortality in type 2 diabetes (ZODIAC-16). Diabetes Care 2009 Nov 16. [Epub ahead of print] Go to original source... Go to PubMed...
  18. Evans JM, Donnelly LA, Emslie-Smith AM, et al. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005; 330: 1304-1305. Go to original source... Go to PubMed...
  19. Libby G, Donnelly LA, Donnan PT, et al. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 2009; 32(9): 1620-1625. Go to original source... Go to PubMed...
  20. Goodwin PJ, Pritchard KI, Ennis M, et al. Insulin-lowering effects of metformin in women with early breast cancer. Clin Breast Cancer. 2008; 8(6): 501-505. Go to original source... Go to PubMed...
  21. Liu B, Fan Z, Edgerton SM, et al. Metformin induces unique biological and molecular responses in triple negative breast cancer cells. Cell Cycle 2009; 1, 8(13): 2031-2040. Go to original source... Go to PubMed...
  22. Cazzaniga M, Bonanni B, Guerrieri-Gonzaga A, Decensi A. Is it time to test metformin in breast cancer clinical trials? Cancer Epidemiol Biomarkers Prev. 2009; 18(3): 701-705. Go to original source... Go to PubMed...
  23. Rattan R, Giri S, Hartmann L, Shridhar V. Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner. J Cell Mol Med. 2009 Oct 29. [Epub ahead of print]. Go to original source... Go to PubMed...
  24. Wang LW, Li ZS, Zou DW, et al. Metformin induces apoptosis of pancreatic cancer cells. J Gastroenterol. 2008; 21, 14(47): 7192-7198. Go to original source... Go to PubMed...
  25. Zakikhani M, Dowling RJ, Sonenberg N, Pollak MN. The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prev Res (Phila Pa). 2008; 1(5): 369-375. Go to original source... Go to PubMed...




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