Interní Med. 2011; 13(4): 154-158

The changing paradigm of insulin treatment in diabetes type 2

prof.MUDr.Jaroslav Rybka, DrSc.

Diabetologické centrum IK IPVZ, Krajská nemocnice T. Bati a.s., Zlín

The management of diabetes mellitus type 2 (DM2T) is primarily aimed at dysglycaemia, with an objective to reduce the risk of micro- and

macrovascular complicatioons. However, even the new antidiabetic oral drugs themselves are not able to ensure appropriate efficiency in

terms of reaching and maintaining continued therapeutic goals. If it is impossible to provide adequate glycaemic control in a patient with

diabetes type 2, insulin therapy is initiated without any hesitation and delay. The paper looks at rational absolute as well as relative insulin

indications in DM2T, and discusses strategic options related to insulin replacement therapy and its patterns. Indication for insulin analogues

are discussed in more deatail. The aim of insulin therapy is to keep blood sugar and/or HbA1c levels as low as possible, while, at the same

time, avoiding more severe hypoglycaemias, and, in compliance with these guidelines, to select an appropriate insulin regimen.

indications.

Keywords: initiation of insulin therapy in DM2T, absolute and relative insulin indications, insulin regimen alternatives, insulin analogue

Published: April 13, 2011  Show citation