Interní Med. 2011; 13(5): 205-208

Contrast - induced nephropathy

MUDr.Jan Svojanovský, doc.MUDr.Kamil Ševela, CSc., prof.MUDr.Miroslav Souček, CSc.

II. interní klinika FN u sv. Anny v Brně a LF MU, Brno

Contrast-induced nephropathy (CIN) is an iatrogenic renal impairment developing after administration of contrast medium (CM). The

incidence of this condition has recently increased with the increasing use of diagnostic and interventional radiological procedures. The

pathogenesis of CIN involves a wide range of processes affecting the renal parenchyma, such as intrarenal vasoconstriction and medullary

ischemia, direct tubulotoxic effect of CM, oxidative stress and apoptosis. There are numerous factors that increase the risk of developing

CIN, particularly preexisting renal damage, diabetes mellitus, medications and the type and amount of CM. Measures preventing

the development of CIN primarily include renal function assessment, proper hydration, discontinuation of risk-related medication and

minimizing the amount of CM. Also considered is preventive administration of acetylcysteine or theophylline.

Keywords: nephropathy, contrast medium, risk factors, preventive measures

Published: June 1, 2011  Show citation