Interní Med. 2011; 13(9): 329-333

Vitamin D and frailty

prof.MUDr.Hana Matějovská Kubešová, CSc.¹, MUDr.Jana Tůmová², MUDr.Vlasta Polcarová¹, MUDr.Hana Meluzínová¹

¹ Klinika interní, geriatrie a praktického lékařství LF MU a FN Brno

² Oddělení klinické biochemie FN Brno

Frailty syndrome comprises not only emerging fractures caused by instability and falls, but complex of pathologies as frequent organ

decompensations, infective complications, psychical problems and rapid cognitive decline accelerating the appearance of disability and

dependency of seniors. Vitamin D as one of liposolubile vitamins was related to children age and skeleton at the clinical practice until

now. There is lot of new information considering rather more complicated connection of vitamin D into many functions of human body

during last years. This review shows actual information about relationship between vitamin D and organ systems and their disturbances.

Long term low level of vitamin D potentiates cognitive deterioration in elderly, influences the mood up to depression appearance. The

influence of vitamin D on imunity system and cancerogenesis appears to be of high importance too. From the senior´s independence

point of view the relationship between vitamin D and sarcopenia is very important especially in connection with osteoporosis prevention

– the way how to reduce the danger of falls and osteoporotic fractures. Autoimmune diseases and diabetes mellitus are mentioned

at the end of the review.

Keywords: frailty, vitamin D, bone, muscle, sarcopenia, cognitive functions, depression, cancer, autoimunity, diabetes mellitus

Published: September 1, 2011  Show citation