Interní Med. 2012; 14(3): 104-106
Barrett´s esophagus, risk factors and management
- Interní gastroenterologická klinika, LF MU a Fakultní nemocnice Brno
Barrett´s esophagus (BE) is a premalignant lesion developed due to chronic gastroesophageal reflux. The squamous esophageal mucosa
is replaced by columnar epithelium. The squamocolumnar junction is displaced proximally and metaplastic epithelium should be
confirmed from biopsy samples. The risk of development of adenocarcinoma is 30–40 times higher in patiens with BE than in patients
without this condition. Incidence of cancer in patients with BE is approximatelly 0,2–0,5 % per year. Endoscopic surveillance program has
been established to diagnose early dysplasia and cancer. Antireflux therapy by acid suppressant drugs or surgery is an important part of
management. Guidelines for the surveillance and management have been published. High grade dysplasia and early adenocarcinoma
can be succesfully treated endoscopically. The surgical resection as an alternative option.
therapy.
Keywords: gastroesophageal reflux disease, Barrett´s esofagus, premalignant, proton pump inhibitors, fundoplication, endoscopic
Published: March 26, 2012 Show citation
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