Interní Med. 2012; 14(3): 125-128

Parathyroid carcinoma

MUDr.Milan Halenka, Ph.D.1, doc.MUDr.David Karásek, Ph.D.1, doc.MUDr.Zdeněk Fryšák, CSc.1, doc.MUDr.Pavel Koranda, Ph.D.2
1 III. interní klinika, FN a LF UP Olomouc
2 Klinika nukleární medicíny, FN a LF UP Olomouc

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. It may be suspected based on severe clinical signs, significant laboratory

findings and the tumor size. The clinical signs of primary hyperparathyroidism are dominated by recurrent nephrolithiasis, bone

disease, hypercalcemic syndrome and uncontrollable hypercalcemic crisis may occur. The basic therapeutic approach is radical surgery.

ultrasonography, technetium-99m sestamibi.

Keywords: parathyroid carcinoma, primary hyperparathyroidism, parathyroid carcinoma, hypercalcemic syndrome, high-resolution

Published: March 26, 2012  Show citation

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Halenka M, Karásek D, Fryšák Z, Koranda P. Parathyroid carcinoma. Interní Med. 2012;14(3):125-128.
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    References

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    4. Cheah WK, Rauff A, Lee KO, et al. Parathyroid carcinoma: a case series. Ann Acad Med Singapore 2005; 34: 443-446.
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    29. Clayman GL, Gonzalez HE, El-Naggar A, et al. Parathyroid carcinoma: evaluation and interdisciplinary management. Cancer 2004; 100: 900-905. Go to original source... Go to PubMed...
    30. Sacks BA, Pallotta JA, Cole A, et al. Diagnosis of parathyroid adenomas: efficacy of measuring parathormone levels in needle aspirates of cervical masses. Am J Roentgenol 1994; 163: 1223-1226. Go to original source... Go to PubMed...
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    36. Shane E. Clinical review: 122 Parathyroid carcinoma. J Clin Endocrinol Metab 2001; 86: 485-493. Go to original source... Go to PubMed...
    37. De Lelis RA, Mazzaglia P, Mangray S. Primary hyperparathyroidism: a current perspective. Arch Pathol Lab Med 2008; 132: 1251-1262. Go to original source...
    38. Pai SI, Goldstein BJ, Studeman KD, et al. Concurrent sporadic parathyroid adenoma and carcinoma. Am J Otolaryngol 2006; 27: 346-348. Go to original source... Go to PubMed...
    39. Cheah WK, Rauff A, Lee KO, et al. Parathyroid carcinoma: a case series. Ann Acad Med Singapore 2005; 34: 443-446.
    40. Wynne AG, van Heerden J, Carney JA, et al. Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine (Baltimore) 1992; 71: 197-205. Go to original source... Go to PubMed...
    41. Haber RS, Kim CK, Inabnet WB. Ultrasonography for preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism: comparison with (99m) technetium sestamibi scintigraphy. Clin Endocrinol (Oxf) 2002; 57: 241-249. Go to original source... Go to PubMed...
    42. Whitson BA, Broadie TA. Preoperative Preoperative ultrasound and nuclear medicine studies improve the accuracy in localization of adenoma in hyperparathyroidism. Surg Today 2008; 38: 222-226. Go to original source... Go to PubMed...
    43. Ulanovski D, Feinmesser R, Cohen M, et al. Preoperative evaluation of patients with parathyroid adenoma: role of high-resolution ultrasonography. Head Neck 2002; 24: 1-5. Go to original source... Go to PubMed...
    44. Abboud B, Sleilaty G, Rabaa L, et al. Ultrasonography: highly accuracy technique for preoperative localization of parathyroid adenoma. Laryngoscope 2008; 118: 1574-1578. Go to original source... Go to PubMed...
    45. Hara H, Igarashi A, Yano Y, et al. Ultrasonographic features of parathyroid carcinoma. Endocr J 2001; 48: 213-217. Go to original source... Go to PubMed...
    46. Halenka M, Klusová N, Fryšák Z, et al. Karcinom příštítného tělíska, vzácná příčina hyperkalcémie u pacienta s B-NHL. Interní Med 2009; 11: 42-44.
    47. Christmas TJ, Chapple CR, Noble JG, et al. Hyperparathyroidism after neck irradiation. Br J Surg 1988; 75: 873-874. Go to original source... Go to PubMed...
    48. Dionisi S, Minisola S, Pepe J, et al. Concurrent parathyroid adenomas and carcinoma in the setting of multiple endocrine neoplasia type 1: presentation as hypercalcemic crisis. Mayo Clin Proc 2002; 77: 866-869. Go to original source... Go to PubMed...
    49. Fraker DL. Update on the management of parathyroid tumors. Curr Opin Oncol 2000; 12: 41-48. Go to original source... Go to PubMed...
    50. Sotorník R, Anděl M. Karcinom příštítného tělíska: vzácná příčina primární hyperparatyreózy. DMEV 2005; 8: 23-28.
    51. Schantz A, Castleman B. Parathyroid carcinoma. A study of 70 cases. Cancer 1973; 31: 600-605. Go to original source...
    52. Hundahl SA, Fleming ID, Fremgen AM, et al. Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995: a National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1999; 86: 538-544. Go to original source...
    53. Shane E. Clinical review 122: Parathyroid carcinoma. J Clin Endocrinol Metab 2001; 86: 485-493. Go to original source... Go to PubMed...
    54. Wynne AG, van Heerden J, Carney JA, et al. Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine. Baltimore 1992; 71: 197-205. Go to original source... Go to PubMed...
    55. Cheah WK, Rauff A, Lee KO, et al. Parathyroid carcinoma: a case series. Ann Acad Med Singapore 2005; 34: 443-446.
    56. Stewart AK, Bland KI, McGinnis LS Jr, et al. Clinical highlights from the National Cancer Data Base, 2000. CA Cancer J Clin 2000; 50: 171-183. Go to original source... Go to PubMed...
    57. Moran CA, Suster S. Primary parathyroid tumors of the mediastinum: a clinicopathologic and immunohistochemical study of 17 cases. Am J Clin Pathol 2005; 124: 749-754. Go to original source...
    58. Chiofalo MG, Scognamiglio F, Losito S, et al. Huge parathyroid carcinoma: clinical considerations and literature review. J Surg Oncol 2005; 3: 39. Go to original source...
    59. Power C, Kavanagh D, Hill AD, et al. Unusual presentation of a giant parathyroid adenoma: report of a case. Surg Today 2005; 35: 235-237. Go to original source... Go to PubMed...
    60. Castillo L, Poissonnet G, Haddad A, et al. Parathyroid carcinoma: diagnosis and treatment. Rev Laryngol Otol Rhinol (Bord) 2000; 121: 169-173. Go to PubMed...
    61. Pelizzo MR, Piotto A, Bergamasco A, et al. Parathyroid carcinoma. Therapeutic strategies derived from 20 years of experience. Minerva Endocrinol 2001; 26: 23-29.
    62. Cordeiro AC, Montenegro FL, Kulcsar MA, et al. Parathyroid carcinoma. Am J Surg 1998; 175: 52-55. Go to original source... Go to PubMed...
    63. Chang YJ, Mittal V, Remine S, et al. Correlation between clinical and histological findings in parathyroid tumors suspicious for carcinoma. Am Surg 2006; 72: 419-426. Go to original source... Go to PubMed...
    64. Clayman GL, Gonzalez HE, El-Naggar A, et al. Parathyroid carcinoma: evaluation and interdisciplinary management. Cancer 2004; 100: 900-905. Go to original source... Go to PubMed...
    65. Sacks BA, Pallotta JA, Cole A, et al. Diagnosis of parathyroid adenomas: efficacy of measuring parathormone levels in needle aspirates of cervical masses. Am J Roentgenol 1994; 163: 1223-1226. Go to original source... Go to PubMed...
    66. Munson ND, Foote RL, Northcutt RC, et al. Parathyroid carcinoma: is there a role for adjuvant radiation therapy? Cancer 2003; 98: 2378-2384. Go to original source... Go to PubMed...
    67. Kebebew E. Parathyroid carcinoma. Curr Treat Options Oncol 2001; 2: 347-354. Go to original source... Go to PubMed...
    68. Rasmuson T, Kristoffersson A, Boquist L. Positive effect of radiotherapy and surgery on hormonally active pulmonary metastases of primary parathyroid carcinoma. Eur J Endocrinol 2000; 143: 749-754. Go to original source... Go to PubMed...
    69. Calandra DB, Chejfec G, Foy BK, et al. Parathyroid carcinoma: biochemical and pathologic response to DTIC. Surgery 1984; 96: 1132-1137. Go to PubMed...
    70. Sharretts JM, Kebebew E, Simonds WF. Parathyroid cancer. Semin Oncol 2010; 37: 580-590. Go to original source... Go to PubMed...

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