Interní Med. 2013; 15(3-4): 125-129

Toxoallergic puzzle - clinical symptoms of metal toxicity and allergy. Case report

MUDr.Jan Maňoušek¹, RNDr.Jiřina Bártová, CSc.², RNDr.Štěpán Podzimek, Ph.D.², doc.MUDr.Jarmila Procházková, CSc.²

Interní kardiologická klinika FN Brno1;

² Ústav klinické a experimentální stomatologie Praha

Environmental factors are one of the causes of increased incidence of allergic, autoimmune, degenerative and demyelinating diseases.

These also include highly reactive metal ions being slowly released from dental fillings and other implants or those contained in products

of daily needs. In susceptible individuals they activate T-lymphocytes and trigger a chronic systemic inflammatory response. Production of

cytokines and increased oxidative stress lead to changes in tissues and organs. Clinically it may present with non-specific range of gradually

progressive, very stubborn and “unexplained” symptoms which are difficult to investigate but significantly impair quality of life. In addition to

routine toxicological testing the diagnostics is based mainly on the Melisa test. This proves the reactivity of memory cells of the immune

system to the appropriate metal. Removal of incompatible materials leads to long-term health improvement in most of the patients (1).

Keywords: amalgam, metal toxicity, immunopathological reactions, Melisa test, cytokines, oxydative stress, chronic fatigue syndrom (CFS)

Published: March 20, 2013  Show citation