Interní Med. 2013; 15(5): 160-162
Diabetic gastropathy: myths and reality in the new decade
- Interní klinika IPVZ Zlín, Krajská nemocnice T. Bati a.s., Zlín
Diabetic gastroparesis affects type 1 as well as type 2 diabetic patients. Its development is not determined by the duration and severity
of diabetes or the presence of organ complications. It is the degenerative changes in the enteric nervous system and interstitial cells of
Cajal (ICC) in chronic oxidative stress and nutritional factor deficiency along with involvement of autoimmunity that play an aetiological
role in its development. Scintigraphy with radionuclide-labelled solid meal is the gold standard in diagnosing the condition. Indigestion
does not correlate with the rate of gastric emptying. The treatment of gastroparesis requires good diabetes control, nutritional support,
and prokinetics, with itopride being the most effective. Ghrelin analogues are being tested. Pharmacological prevention of damage with
antioxidants and hem1-oxidase inhibitors appears promising.
Keywords: diabetic gastroparesis, prokinetics, pathogenesis, treatment
Published: June 1, 2013 Show citation
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