Interní Med. 2013; 15(6-7): 236-239

Perioperative management of anticoagulant therapy

MUDr.František Kováčik, MUDr.Ondřej Moravec, doc.MUDr.Petr Heinc, Ph.D.
I. interní klinika &ndash, kardiologická, Fakultní nemocnice Olomouc

Perioperative management of patients on anticoagulant therapy involves assessing and balanci ng individual risks for thromboembolism

and bleeding. Discontinuing peroral anticoagulant therapy is usually necessary for most surgical procedures but increases the risk

of thrombotic events. Temporary periprocedural substitution of low-molecular-weight heparin or unfractionated heparin in place of

warfarin, is an effective means of reducing the risk of thromboembolism but may increase the risk of bleeding. The timing of warfarin

withdrawal and timing of the preoperative and postoperative apllication of parenenteral anticoagulant are critical to balancing these risks.

Keywords: anticoagulant therapy, operation, warfarin

Published: July 15, 2013  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Kováčik F, Moravec O, Heinc P. Perioperative management of anticoagulant therapy. Interní Med. 2013;15(6-7):236-239.
Download citation

References

  1. Perry DJ, Noakes TJ, Helliwell PS, British Dental Society. Guidelines for the management of patients on oral anticoagulants requiring dental surgery. Br Dent J 2007; 203: 389. Go to original source... Go to PubMed...
  2. Nelms JK, Wooten AI, Heckler F. Cutaneous surgery in patients on warfarin therapy. Ann Plast Surg 2009; 62: 275. Go to original source... Go to PubMed...
  3. Anderson MA, Ben-Menachem T, Gan SI, et al. Management of antithrombotic agents for endoscopic procedures. Gastrointest Endosc 2009; 70:1060. Go to original source... Go to PubMed...
  4. Korantzopoulos P, Letsas KP, Liu T, et al. Anticoagulation and antiplatelet therapy in implantation of electrophysiological devices. Europace 2011; 13: 1669. Go to original source... Go to PubMed...
  5. Goldstein DJ, Losquadro W, Spotnitz HM. Outpatient pacemaker procedures in orally anticoagulated patients. Pacing Clin Electrophysiol 1998; 21: 1730. Go to original source... Go to PubMed...
  6. Kiviniemi T, Karjalainen P, Pietilä M, et al. Comparison of additional versus no additional heparin during therapeutic oral anticoagulation in patients undergoing percutaneous coronary intervention. Am J Cardiol 2012; 110: 30. Go to original source... Go to PubMed...
  7. Go AS, Hylek EM, Chang Y, et al. Anticoagulation therapy for stroke prevention in atrial fibrillation: how well do randomized trials translate into clinical practice? JAMA 2003; 290: 2685. Go to original source... Go to PubMed...
  8. Levine MN, Hirsh J, Gent M, et al. Optimal duration of oral anticoagulant therapy: a randomized trial comparing four weeks with three months of warfarin in patients with proximal deep vein thrombosis. Thromb Haemost 1995; 74: 606. Go to original source... Go to PubMed...
  9. Loh E, Sutton MS, Wun CC, et al. Ventricular dysfunction and the risk of stroke after myocardial infarction. N Engl J Med 1997; 336: 251. Go to original source... Go to PubMed...
  10. Douketis JD, Foster GA, Crowther MA, et al. Clinical risk factors and timing of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapy. Arch Intern Med 2000; 160: 3431. Go to original source... Go to PubMed...
  11. White RH, McKittrick T, Hutchinson R, Twitchell J. Temporary discontinuation of warfarin therapy: changes in the international normalized ratio. Ann Intern Med 1995; 122: 40. Go to original source... Go to PubMed...
  12. Levy JH, Tanaka KA, Dietrich W. Perioperative hemostatic management of patients treated with vitamin K antagonists. Anesthesiology 2008; 109: 918. Go to original source... Go to PubMed...
  13. Douketis JD, Spyropoulos AC, Spencer FA, et al. Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141: e326S. Go to original source...
  14. Gumulec J, Penka M, Bezděk R, et al. Prevence žilni tromboembolické nemoci: Obecně platná pravidla. Vnitr Lek. 2006; 52(Suppl 1): 6-16. Go to PubMed...
  15. James D. Douketis, Perioperative management of patients who are receiving warfarin therapy: an evidence-based and practical approach. Blood 2011; 117: 5044-5049. Go to original source... Go to PubMed...




Internal Medicine for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.