Interní Med. 2013; 15(8-9): 245-247

Fixed combinations in the management of arterial hypertension

MUDr.Jan Přeček, MUDr.František Kováčik
I. interní klinika kardiologická FN a LF UP Olomouc

Arterial hypertension is a significant cardiovascular risk factor. Monotherapy fails to result in the expected therapeutic effect in the majority

of patients. To achieve target blood pressure levels, about two thirds of patients require the use of combination therapy. However,

compliance with treatment decreases with the increasing number of medications. The studies performed suggest that fixed combinations

lead to improved patient adherence and compliance. According to the current guidelines for the management of arterial hypertension,

the use of fixed combinations has its role as early as initiation of treatment.

Keywords: arterial hypertension, combination therapy, fixed combination

Published: October 1, 2013  Show citation

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Přeček J, Kováčik F. Fixed combinations in the management of arterial hypertension. Interní Med. 2013;15(8-9):245-247.
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    References

    1. Cífková R, Bruthans J, Adámková V, et al. Prevalence základních kardiovaskulárních rizikových faktorů v české populaci v letech 2006-2009. Studie Czech post-MONICA. Cor Vasa 2011; 53: 220-229. Go to original source...
    2. Okonofua EC, Simpson KN, Jesri A, Rehman SU, Durkalski VL, Egan BM. Therapeutic inertia Is an impediment to achieving the healthy people 2010 blood pressure control goals. Hypertension. 2006; 47: 345-351. Go to original source... Go to PubMed...
    3. Filipovský J, Widimský J, Ceral J, et al. Diagnostické a léčebné postupy u arteriální hypertenze - verze 2012. Doporučení České společnosti pro hypertenzi. Vnitř Lék 2012; 58(10): 785-801. Go to PubMed...
    4. Bakris GL. The importance of blood pressure control in the patient with diabetes. Am J Med. 2004; 116: 30S-38S. Go to original source... Go to PubMed...
    5. Jamerson K, Weber MA, Bakris GL, et al. for the ACCOMPLISH trial investigators. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008; 359: 2417-2428. Go to original source... Go to PubMed...
    6. Wald DS, Law M, Morris JK, et al. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med 2009; 122: 290-300. Go to original source... Go to PubMed...
    7. Park CG. Recent Update on Fixed Combinations of Antihypertensive Agents. Korean Circ J 2008; 38: 237-243. Go to original source...
    8. Kalra S, Kalra B, Agrawal N. Combination therapy in hypertension: An update. Diabetol Metab Syndr 2010; 2: 44. Go to original source... Go to PubMed...
    9. ONTARGET Investigators. Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events. N Engl J Med 2008; 358: 1547-1155. Go to original source... Go to PubMed...
    10. Dahlöf B, Sever PS, Poulter NR, et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895-906. Go to original source... Go to PubMed...
    11. PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood pressure lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001; 358: 1033-1041. Go to original source... Go to PubMed...
    12. Patel A. ADVANCE Collaborative Group, MacMahon S, et al. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet 2007; 370: 829-840. Go to original source... Go to PubMed...
    13. Makita S, Abiko A, Naganuma Y, et al. Efficacy of low-dose hydrochlorothiazide in combination with telmisartan on early morning blood pressure in uncontrolled hypertensive patients. Clin Exp Hypertens 2009; 31: 105-115. Go to original source... Go to PubMed...
    14. Dahlof B, Devereux RB, Kjeldsen SE for the LIFE investigators: Cardovascular morbidity and mortality in the Losartan Intervention For Endpoints reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 995-1003. Go to original source... Go to PubMed...
    15. Matsuzaki M, Ogihara T, Umemoto S, et al. Combination Therapy of Hypertension to Prevent Cardiovascular Events Trial Group. Prevention of cardiovascular events with calcium channel blocker-based combination therapies in patients with hypertension: a randomized controlled trial. J Hypertens 2011; 29: 1649-1659. Go to original source... Go to PubMed...
    16. Makani H, Bangalore S, Desouza KA, et al. Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials. BMJ 2013; 346: f360 doi: 10.1136/bmj.f360. Go to original source... Go to PubMed...
    17. Gerbino PP, Shoheiber O. Adherence patterns among patients treated with fixed-dose combination versus separate antihypertensive agents. Am J Health Syst Pharm 2007; 64: 1279-1283. Go to original source... Go to PubMed...
    18. Sokol MC, McGuigan KA, Verbrugge RR, et al. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 2005; 43: 521-530. Go to original source... Go to PubMed...
    19. Bangalore S, Kamalakkannan G, Parkar S, et al. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med 2007; 120: 713-719. Go to original source... Go to PubMed...
    20. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension 2010; 55: 399-407. Go to original source... Go to PubMed...

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