Interní Med. 2013; 15(11-12): 349-351

Renal Denervation

prof.MUDr.Václav Monhart, CSc.
Univerzita Karlova v Praze, 1. lékařská fakulta a Ústřední vojenská nemocnice Praha, Interní klinika
Synlab Czech s.r.o., Nefrologická ambulance Praha

Renal denervation is an invasive method of treatment resistant hypertension. Percutaneous transluminal catheter-based ablation of the

sympathetic nerve endings in the wall of the renal arteries leads to a reduction in blood pressure, which persists for up to 3 years. The

largest and longest experience is evidenced by the renal denervation system Symplicity (Medtronic). The study of Symplicity HTN-1 and

Symplicity HTN-2 confirmed the safety and effectiveness of the procedures. The development of new renal denervation catheter-based

systems is promising in terms of greater efficiency, shorter duration and safety of the treatment.

Keywords: renal denervation, sympathetic nervous system, resistant hypertension, catheter-based ablation, denervation systems

Published: December 1, 2013  Show citation

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Monhart V. Renal Denervation. Interní Med. 2013;15(11-12):349-351.
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    References

    1. Calhoun DA, Jones D, Textor S, et al. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation. 2008; 117(25): e510-526. Go to original source... Go to PubMed...
    2. Schlaich MP, Sobotka PA, Krum H, et al. Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med 2009; 361: 932-934. Go to original source... Go to PubMed...
    3. Widimský P, Osmančík P, Widimský J, jr. Renální denervace: naděje pro nemocné s refrakterní hypertenzí? Cor Vasa 2011; 53(10): 517-521. Go to original source...
    4. Widimský P, Filipovský J, Widimský J Jr, Branny M, Monhart V, Táborský M. Odborné stanovisko České kardiologické společnosti a České společnosti pro hypertenzi k provádění katetrizačních renálních denervací (RDN) v České republice. Cor et Vasa 2012; 54(3-4): 155-159. Go to original source...
    5. Templin Ch, Jaguszewski M, Ghadri JR, et al.Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity(R) catheter system and the EnligHTN(TM) multi-electrode renal denervation catheter. Eur Heart J 2013, doi: 10.1093/eurheartj/eht141. Go to original source... Go to PubMed...
    6. Krum H, Schlaich M, Whitbourn R, et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 2009; 373: 1275-1281. Go to original source... Go to PubMed...
    7. Symplicity HTN-1 Investigators. Catheter-based renal sympathetic denervation for resistant hypertension: durability of blood pressure reduction out to 24 months. Hypertension 2011; 57: 911-917. Go to PubMed...
    8. Krum H, Barman N, Schlaich M, et al. Long-term follow-up of catheter-based renal sympathetic denervation for resistant hypertension confirms durable blood pressure reduction. J Am Coll Cardiol 2012; 59: E1704. Go to original source...
    9. Sudano I, Mahfoud F. Renal nerve abltion for treatment of therapy-resistant hypertension. Eur Heart J 2013; 34(12): 865-868.
    10. Esler MD, Krum H, Sobotka PA, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 2010; 376: 1903-1909. Go to original source... Go to PubMed...
    11. Esler MD, Krum H, Schlaich M, et al. Renal sympathetic denervation for treatment of drug-resistant hypertension: One year results from the Symplicity HTN-2 randomized controlled trial. Circulation 2012; 126: 2976-2982. Go to original source... Go to PubMed...
    12. Esler MD, Krum H, Schlaich M, et al. Catheter-based renal sympathetic denervation in patiens with resistant hypertension: 18 month follow-up of the Symplicity HTN-2 trial. European Society of Cardiology 2012 Congress; August 26, 2012; Munich, Germany. Abstract 1163.
    13. Mafeld S, Vasdev N, Haslam P. Renal Denervation for Treatment-Resistant Hypertension. Ther Adv Cardiovasc Dis 2012; 6(6): 245-258. Go to original source... Go to PubMed...
    14. Mahfoud F, Lüscher TF, Andersson B, et al. Expert consensus document from the European Society of Cardiology on catheter-based renal denervation.Eur Heart J 2013; DOI: 10.1093/eurheart/eht 154. Go to original source... Go to PubMed...
    15. DiBona GF. Sympathetic nervous systém and hypertension. Hypertension 2013; 61: 556-560. Go to original source... Go to PubMed...

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