Interní Med. 2013; 15(11-12): 346-348
Options of flexible insulin administration
- Diabetologická ambulance, Poliklinika Barrandov, Praha
Insulin analogs are biosynthetically made insulins that differ from human insulins in the modification of amino acids in the chains at
certain positions. The reason for this modification is altered insulin pharmacokinetics that, as a result, imitates the physiological secretion
of endogenous insulin to a higher extent. A resulting advantage of insulin analogs in comparison to human insulins in their clinical use is
reduced blood glucose fluctuation and, in the case of long-acting insulin analogs, particularly a lower risk of hypoglycemias, especially
nocturnal ones, lower weight gain in patients, and flexible insulin administration.
Keywords: long-acting insulin analogs, pharmacokinetics of insulin analogs, novel long-acting insulin analog degludec, flexible insulin administration
Published: December 1, 2013 Show citation
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- Souhrn údajů o přípravku Tresiba (poslední revize textu 01/2013).