Interní Med. 2014; 16(3): 102-105 [Med. praxi. 2014;11(1):22-25]
The use of strong opioids in chronic pain treatment
- Centrum pro léčbu bolesti a paliativní medicínu, s. r. o., Zlín
The effective management of chronic pain is fundamental goal for all clinicians, who treat the pain. Nociceptive and neuropathic pain
are two basic kinds of pain, which appears separetly or in combination. The three-step analgesic ladder developed by the World Health
Organisation (WHO) outlines these opioids in the management of cancer pain, and these widely accepted and extensively validated
guidelines have also been influential in the application of opioid therapy for treatment of chronic, non-malignant pain. Potent opioids
– such as morfin and the newer-generation agents (fentanyl, buprenorfin, oxycodon, hydromorfon and tapentadol) play an important
role in management of pain in patients with chronic pain. New opioid tapentadol is the first compound of the new pharmacological class
MOR-NRI, that combines μ-opioid-agonist and noradrenalin re-uptake inhibitor activities in one molecule.
Keywords: gabapentinoids drugs, opioids drugs, oxycodon, naloxon, tapentadol
Published: May 26, 2014 Show citation
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