Interní Med. 2014; 16(4): 156-158

Non-corpuscular hyperviscosity syndrome in clinical practice

MUDr.Tomáš Pika, Ph.D.¹, MUDr.Zdenka Kosatíková¹, Mgr.Jarmila Juráňová², MUDr.Petr Mlčák³

¹ III. interní klinika &ndash, nefrologická, revmatologická, endokrinologická, LF UP a FN Olomouc

² Hemato-onkologická klinika, FN Olomouc

³ Oční klinika, FN Olomouc

Hyperviscosity syndrome (HVS) from non-corpuscular cause is a clinical and laboratory syndrome due to increased blood viscosity, mostly

caused by excessive levels or modified physical and chemical characteristics of serum immunoglobulins. Clinical features of HVS are typical

in patients with monoclonal gammopathies – multiple myeloma and Waldenström´s macroglobulinemia. They can be, however, found in

other conditions such as cryoglobulinemia or systemic connective tissue disorders. The presence of clinical manifestation accompanied

with decreased organ perfusion, and laboratory confirmation of increased viscosity are the major aspects supporting plasmapheresis

as supportive treatment modality in these patients.

Keywords: non-corpuscular viscosity, viscosity, hyperviscosity syndrome, plasmapheresis

Published: June 1, 2014  Show citation