Interní Med. 2016; 18(4): 168-175 | DOI: 10.36290/int.2016.039
Current approaches to combination therapy of hypertension
- Centrum pro výzkum, diagnostiku a léčbu hypertenze
- III. interní klinika 1. LF UK a VFN v Praze
In light of current knowledge, combination therapy of hypertension involving, in particular, the administration of drugs affecting the renin–angiotensin–aldosterone system, calcium channel blockers, and diuretics in fixed combinations represents a gold standard. Due to different mechanisms of action of the individual agents, these combinations of antihypertensive drugs have a significant additive and synergic antihypertensive effect leading to a more pronounced reduction in blood pressure and lower rates of adverse events of the individual components. Prescription of fixed combinations also increases patient compliance. Moreover, selection of a wide range of doses of the individual components allows their administration to patients with various degrees of arterial hypertension.
Keywords: arterial hypertension, combination therapy, fixed combination, compliance
Published: September 1, 2016 Show citation
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