Interní Med. 2016; 18(5): 226-230 | DOI: 10.36290/int.2016.052

Possibilities of IFN-free therapy of hepatitis C

prof. MUDr. Petr Husa, CSc., MUDr. Petr Husa ml.
Klinika infekčních chorob LF MU a FN Brno, Brno

Chronic hepatitis C therapy using Directly Acting Antivirals (DAA) has high efficacy (till 100 %), minimum contra-indications and extraordinarily favorable safety profile. Primarily, it is necessary to pay attention to drug-drug interactions. However they are well documented and successfully resolvable already in general clinical practice. Current possibilities of interferon-free therapy represent combinations of sofosbuvir with other DAA or with ribavirin and combination of paritaprevir boosted by ritonavir + ombitasvir ± dasabuvir. Fixed combinaton of elbasvir and grazoprevir is already available in some countries of the world.

Keywords: chronic hepatitis C, sofosbuvir, ledipasvir, velpatasvir, paritaprevir, ombitasvir, dasabuvir, elbasvir, grazoprevir

Published: December 1, 2016  Show citation

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Husa P, Husa P. Possibilities of IFN-free therapy of hepatitis C. Interní Med. 2016;18(5):226-230. doi: 10.36290/int.2016.052.
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