Interní Med. 2017; 19(2): 66-71 | DOI: 10.36290/int.2017.012

Advances in insulin therapy

MUDr. Eva Račická

Diabetologická a interní ambulance Ostrava-Kunčice

Type 2 diabetes mellitus is a chronic and progressive disease, with the goals of treatment being prolonged survival and improved

quality of life. The treatment has to be effective and safe since the initial diagnosis. The underlying pathophysiology for type 2

diabetes mellitus is the combination of insulin resistance and relative, and later on absolute, lack of insulin secretion. This requires

initiation of treatment with insulin which currently involves a wide portfolio of human insulins and, in particular, insulin analogues

that can be safely combined with oral antidiabetic drugs or injection therapy by means of GLP-1 receptor agonists can be used. The

article describes the process of introducing insulin therapy and its combination with treatment with other antidiabetic drugs during

the progression of type 2 diabetes mellitus, the options of combining the individual insulins, and their regimens. Also presented are

some recent advances in insulin therapy: novel long-acting analogues and fixed combination of insulin with GLP-1 receptor agonists.

Keywords: type 2 diabetes mellitus, insulin therapy, insulin analogues, combination of insulin with oral antidiabetics and GLP-1R agonists

Published: April 1, 2017  Show citation