Interní Med. 2017; 19(4): 225-229 | DOI: 10.36290/int.2017.035

Hospital-acquired pneumonia – optimal settings of the initial empirical antibiotic therapy

MUDr. Radovan Uvízl, Ph.D.¹, MUDr. Tomáš Herkeľ¹, prof. MUDr. Milan Kolář, Ph.D.^{2 a pracovní skupina}

¹ 1Klinika anesteziologie, resuscitace a intenzivní medicíny, Fakultní nemocnice Olomouc

a Lékařská fakulta Univerzity Palackého v Olomouci

² 2Ústav mikrobiologie, Fakultní nemocnice Olomouc a Lékařská fakulta Univerzity Palackého v Olomouci

Pracovní skupina: MUDr. Miroslava Htoutou Sedláková, doc. MUDr. Milan Adamus, Ph.D., MBA, MUDr. Lenka Doubravská,

doc. MUDr. Tomáš Gabrhelík, Ph.D., Mgr. Vendula Pudová, Ph.D., MUDr. Kateřina Langová, doc. MUDr. Roman Zazula, Ph.D.,

MUDr. Tomáš Řezáč, MUDr. Michal Moravec, doc. MUDr. Pavel Čermák, CSc., prof. MUDr. Pavel Ševčík, CSc., MUDr. Jan Stašek,

MUDr. Alena Ševčíková, MUDr. Markéta Hanslianová, MUDr. Zdeněk Turek, prof. MUDr. Vladimír Černý, Ph.D., MUDr. Pavla Paterová

Hospital-acquired pneumonia (HAP) is one of the most severe complications occurring in patients during their hospital stayand an important factor affecting the economy of health care; it is often associated with bacterial resistance. The presence ofindividual etiological pathogens causing HAP and their resistance to antimicrobial agents play a key role in the selection of adequateantibiotic therapy. However, not knowing these pathogens usually complicates causative antibiotic therapy at the onsetof pneumonia. It takes hours to days to identify them and, in the meantime, empirical antibiotic therapy must be initiated. Theusual pathogens causing HAP are endogenous bacterial strains originating from the primary microflora in early-onset HAP andsecondary colonizing bacteria with a higher level of resistance in late-onset HAP. The onset of HAP is often manifested by clinicalsigns of sepsis and considerably worsens the prognosis of patients. Therefore, the aims were to obtain current epidemiologicaldata on pathogens causing HAP and to determine their susceptibility to antibiotics. The results were compared with data froma protocol for reference initial empirical antibiotic therapy of HAP so that optimal initial antibiotic therapy of HAP could be set.

Keywords: nosocomial infections, HAP, initial empirical antibiotic therapy, pneumonia

Published: November 1, 2017  Show citation